PF-06305591
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    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H465708

CAS#: 1449473-97-5

Description: PF-06305591 is a potent and highly selective sodium channel Nav1.8 inhibitor.

Chemical Structure

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PF-06305591
CAS# 1449473-97-5
Instruction

Theoretical Analysis

Hodoodo Cat#: H465708
Name: PF-06305591
CAS#: 1449473-97-5
Chemical Formula: C15H22N4O
Exact Mass: 274.18
Molecular Weight: 274.368
Elemental Analysis: C, 65.67; H, 8.08; N, 20.42; O, 5.83

Price and Availability

Size Price Availability Quantity
5mg USD 290 2 Weeks
25mg USD 720 2 Weeks
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Synonym: PF-06305591; PF06305591; PF 06305591;

IUPAC/Chemical Name: (2R,3S)-3-amino-3-(5-(tert-butyl)-1H-benzo[d]imidazol-2-yl)-2-methylpropanamide

InChi Key: APWZIFIAVVFPNT-PELKAZGASA-N

InChi Code: InChI=1S/C15H22N4O/c1-8(13(17)20)12(16)14-18-10-6-5-9(15(2,3)4)7-11(10)19-14/h5-8,12H,16H2,1-4H3,(H2,17,20)(H,18,19)/t8-,12+/m1/s1

SMILES Code: C[C@H]([C@@H](C1=NC2=CC(C(C)(C)C)=CC=C2N1)N)C(N)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 274.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Brown AD, Bagal SK, Blackwell P, Blakemore DC, Brown B, Bungay PJ, Corless M, Crawforth J, Fengas D, Fenwick DR, Gray V, Kemp M, Klute W, Malet Sanz L, Miller D, Murata Y, Payne CE, Skerratt S, Stevens EB, Warmus JS. The discovery and optimization of benzimidazoles as selective NaV1.8 blockers for the treatment of pain. Bioorg Med Chem. 2019 Jan 1;27(1):230-239. doi: 10.1016/j.bmc.2018.12.002. Epub 2018 Dec 4. PMID: 30538065.