WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H465724
CAS#: unknown
Description: ZFH7116 is a TMPRSS2 inhibitor that potently block SARS-CoV-2 and MERS-CoV viral entry and protect human epithelial lung cells.
Hodoodo Cat#: H465724
Name: ZFH7116
CAS#: unknown
Chemical Formula: C37H59N11O8S
Exact Mass: 817.43
Molecular Weight: 818.008
Elemental Analysis: C, 54.33; H, 7.27; N, 18.84; O, 15.65; S, 3.92
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Synonym: ZFH7116; ZFH 7116; ZFH-7116;
IUPAC/Chemical Name: N-((S)-1-amino-3-methyl-1-oxobutan-2-yl)-2-((2-oxopropyl)-L-seryl-L-lysyl-L-leucyl-L-arginyl)benzo[d]thiazole-6-carboxamide
InChi Key: WKTOBYIYIPYICF-RRUDZPKISA-N
InChi Code: InChI=1S/C37H59N11O8S/c1-19(2)15-26(46-33(54)25(9-6-7-13-38)45-35(56)27(18-49)43-17-21(5)50)34(55)44-24(10-8-14-42-37(40)41)30(51)36-47-23-12-11-22(16-28(23)57-36)32(53)48-29(20(3)4)31(39)52/h11-12,16,19-20,24-27,29,43,49H,6-10,13-15,17-18,38H2,1-5H3,(H2,39,52)(H,44,55)(H,45,56)(H,46,54)(H,48,53)(H4,40,41,42)/t24-,25-,26-,27-,29-/m0/s1
SMILES Code: O=C([C@H](CCCNC(N)=N)NC([C@@H](NC([C@H](CCCCN)NC([C@H](CO)NCC(C)=O)=O)=O)CC(C)C)=O)C(S1)=NC2=C1C=C(C(N[C@@H](C(C)C)C(N)=O)=O)C=C2
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 818.01 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Damalanka VC, Voss JJLP, Mahoney MW, Primeau T, Li S, Klampfer L, Janetka JW. Macrocyclic Inhibitors of HGF-Activating Serine Proteases Overcome Resistance to Receptor Tyrosine Kinase Inhibitors and Block Lung Cancer Progression. J Med Chem. 2021 Dec 23;64(24):18158-18174. doi: 10.1021/acs.jmedchem.1c01671. Epub 2021 Dec 13. PMID: 34902246.