ZL0590

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Hodoodo CAT#: H465743

CAS#: unknown

Description: ZL0590 is a Bromodomain-containing Protein 4 (BRD4) BD1 Inhibitor. ZL0590 targeting a unique, previously unreported binding site, while exhibiting significant anti-inflammatory activities in vitro and in vivo.

Chemical Structure

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ZL0590
CAS# unknown
Instruction

Theoretical Analysis

Hodoodo Cat#: H465743
Name: ZL0590
CAS#: unknown
Chemical Formula: C23H27F3N4O4S
Exact Mass: 512.17
Molecular Weight: 512.548
Elemental Analysis: C, 53.90; H, 5.31; F, 11.12; N, 10.93; O, 12.49; S, 6.26

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: ZL0590; ZL 0590; ZL-0590;

IUPAC/Chemical Name: (R)-1-(4-((2-(morpholinomethyl)pyrrolidin-1-yl)sulfonyl)phenyl)-3-(4-(trifluoromethyl)phenyl)urea

InChi Key: ZPMULUKHFNMJPF-HXUWFJFHSA-N

InChi Code: InChI=1S/C23H27F3N4O4S/c24-23(25,26)17-3-5-18(6-4-17)27-22(31)28-19-7-9-21(10-8-19)35(32,33)30-11-1-2-20(30)16-29-12-14-34-15-13-29/h3-10,20H,1-2,11-16H2,(H2,27,28,31)/t20-/m1/s1

SMILES Code: O=C(NC1=CC=C(C(F)(F)F)C=C1)NC2=CC=C(S(=O)(N3[C@@H](CN4CCOCC4)CCC3)=O)C=C2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 512.55 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Liu Z, Li Y, Chen H, Lai HT, Wang P, Wu SY, Wold EA, Leonard PG, Joseph S, Hu H, Chiang CM, Brasier AR, Tian B, Zhou J. Discovery, X-ray Crystallography, and Anti-inflammatory Activity of Bromodomain-containing Protein 4 (BRD4) BD1 Inhibitors Targeting a Distinct New Binding Site. J Med Chem. 2022 Jan 4. doi: 10.1021/acs.jmedchem.1c01851. Epub ahead of print. PMID: 34982556.