WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H465822
CAS#: unknown
Description: Z-505 is a GHS-R1a ligand.
Hodoodo Cat#: H465822
Name: Z-505
CAS#: unknown
Chemical Formula: C28H37N5O4S
Exact Mass: 539.26
Molecular Weight: 539.695
Elemental Analysis: C, 62.31; H, 6.91; N, 12.98; O, 11.86; S, 5.94
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Synonym: Z-505; Z505; Z 505;
IUPAC/Chemical Name: (2R)-2-(2-amino-2-methylpropanamido)-4-methyl-N-(2-oxo-8-(2-oxopyrrolidin-1-yl)-1-(thiophen-3-ylmethyl)-1,2,3,4-tetrahydroquinolin-3-yl)pentanamide
InChi Key: WTPBPKNYMZWUEV-VQCQRNETSA-N
InChi Code: InChI=1S/C28H37N5O4S/c1-17(2)13-20(31-27(37)28(3,4)29)25(35)30-21-14-19-7-5-8-22(32-11-6-9-23(32)34)24(19)33(26(21)36)15-18-10-12-38-16-18/h5,7-8,10,12,16-17,20-21H,6,9,11,13-15,29H2,1-4H3,(H,30,35)(H,31,37)/t20-,21?/m1/s1
SMILES Code: O=C(CCC1)N1C2=C(N(CC3=CSC=C3)C(C(NC([C@H](NC(C(C)(N)C)=O)CC(C)C)=O)C4)=O)C4=CC=C2
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 539.70 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Shiomi Y, Yoshimura M, Hori Y, Ohira Y, Nagahama K, Ozaki T, Takei M, Tanaka T, Uno T. Z-505, an Oral Ghrelin Receptor Agonist, Attenuates Anorexia After Total Gastrectomy in Rats. J Surg Res. 2020 Feb;246:527-534. doi: 10.1016/j.jss.2019.09.035. Epub 2019 Oct 25. PMID: 31668932.
2: Shiomi Y, Ohira Y, Yoshimura M, Ozaki T, Takei M, Tanaka T. Z-505 hydrochloride ameliorates chemotherapy-induced anorexia in rodents via activation of the ghrelin receptor, GHSR1a. Eur J Pharmacol. 2018 Jan 5;818:148-157. doi: 10.1016/j.ejphar.2017.10.047. Epub 2017 Oct 21. PMID: 29066414.
3: Yoshimura M, Shiomi Y, Ohira Y, Takei M, Tanaka T. Z-505 hydrochloride, an orally active ghrelin agonist, attenuates the progression of cancer cachexia via anabolic hormones in Colon 26 tumor-bearing mice. Eur J Pharmacol. 2017 Sep 15;811:30-37. doi: 10.1016/j.ejphar.2017.05.036. Epub 2017 May 18. PMID: 28529141.