WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H465933
CAS#: unknown
Description: WMS-1410 is a novel GluN2B-specific NMDAR antagonist, completely preventing the decrease in insulin secretion of about 32 % provoked by a 24-h-treatment with NMDA/glycine, eliminating NMDA-induced changes in the oxidation status of the islet cells and elevating the sensitivity of intracellular calciumto 15 mM glucose.
Hodoodo Cat#: H465933
Name: WMS-1410
CAS#: unknown
Chemical Formula: C20H25NO2
Exact Mass: 311.19
Molecular Weight: 311.425
Elemental Analysis: C, 77.14; H, 8.09; N, 4.50; O, 10.27
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Synonym: WMS-1410; WMS1410; WMS 1410;
IUPAC/Chemical Name: 3-(4-phenylbutyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepine-1,7-diol
InChi Key: KKLZGWQBNXJWGZ-UHFFFAOYSA-N
InChi Code: InChI=1S/C20H25NO2/c22-18-9-10-19-17(14-18)11-13-21(15-20(19)23)12-5-4-8-16-6-2-1-3-7-16/h1-3,6-7,9-10,14,20,22-23H,4-5,8,11-13,15H2
SMILES Code: OC1CN(CCCCC2=CC=CC=C2)CCC3=CC(O)=CC=C13
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 311.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Markus A, Schepmann D, Wünsch B. Synthesis of oxazolo-annulated 3-benzazepines designed by merging two negative allosteric NMDA receptor modulators. Arch Pharm (Weinheim). 2022 Feb 27:e2200020. doi: 10.1002/ardp.202200020. Epub ahead of print. PMID: 35224754.
2: Gresch A, Hurtado HN, Wörmeyer L, De Luca V, Wiggers R, Seebohm G, Wünsch B, Düfer M. Selective Inhibition of N-Methyl-d-aspartate Receptors with GluN2B Subunit Protects β Cells against Stress-Induced Apoptotic Cell Death. J Pharmacol Exp Ther. 2021 Nov;379(3):235-244. doi: 10.1124/jpet.121.000807. Epub 2021 Sep 30. PMID: 34593560.
3: Ritter N, Korff M, Markus A, Schepmann D, Seebohm G, Schreiber JA, Wünsch B. Deconstruction - Reconstruction: Analysis of the Crucial Structural Elements of GluN2B-Selective, Negative Allosteric NMDA Receptor Modulators with 3-Benzazepine Scaffold. Cell Physiol Biochem. 2021 Mar 3;55(S3):1-13. doi: 10.33594/000000335. PMID: 33656308.
4: Falck E, Begrow F, Verspohl EJ, Wünsch B. In vitro and in vivo biotransformation of WMS-1410, a potent GluN2B selective NMDA receptor antagonist. J Pharm Biomed Anal. 2014 Jun;94:36-44. doi: 10.1016/j.jpba.2014.01.017. Epub 2014 Jan 24. PMID: 24534302.
5: Tewes B, Frehland B, Schepmann D, Schmidtke KU, Winckler T, Wünsch B. Conformationally constrained NR2B selective NMDA receptor antagonists derived from ifenprodil: Synthesis and biological evaluation of tetrahydro-3-benzazepine-1,7-diols. Bioorg Med Chem. 2010 Nov 15;18(22):8005-15. doi: 10.1016/j.bmc.2010.09.026. Epub 2010 Sep 24. PMID: 20965739.