WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H465934
CAS#: unknown
Description: UR-Po563 is a novel H2 receptor agonist, functionally stimulating human cardiac H2 receptors in vitro and in vivo.
Hodoodo Cat#: H465934
Name: UR-Po563
CAS#: unknown
Chemical Formula: C17H24N6OS
Exact Mass: 360.17
Molecular Weight: 360.480
Elemental Analysis: C, 56.64; H, 6.71; N, 23.31; O, 4.44; S, 8.89
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Synonym: UR-Po563; URPo563; UR Po563;
IUPAC/Chemical Name: (R,E)-1-(amino((3-(2-amino-4-methylthiazol-5-yl)propyl)amino)methylene)-3-(1-phenylethyl)urea
InChi Key: QTIAXUAWMLBIGP-LLVKDONJSA-N
InChi Code: InChI=1S/C17H24N6OS/c1-11(13-7-4-3-5-8-13)22-17(24)23-15(18)20-10-6-9-14-12(2)21-16(19)25-14/h3-5,7-8,11H,6,9-10H2,1-2H3,(H2,19,21)(H4,18,20,22,23,24)/t11-/m1/s1
SMILES Code: N/C(NCCCC1=C(C)N=C(N)S1)=N\C(N[C@@H](C2=CC=CC=C2)C)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 360.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Gergs U, Büxel ML, Bresinsky M, Kirchhefer U, Fehse C, Höring C, Hofmann B, Marušáková M, Čináková A, Schwarz R, Pockes S, Neumann J. Cardiac Effects of Novel Histamine H2 Receptor Agonists. J Pharmacol Exp Ther. 2021 Nov;379(3):223-234. doi: 10.1124/jpet.121.000822. Epub 2021 Sep 17. PMID: 34535565.