DC-LC3in-D5

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H465944

CAS#: unknown

Description: DC-LC3in-D5 is a novel potent covalent inhibitor of the autophagic ubiquitin-like protein LC3, targeting LC3A/B and compromising LC3B lipidation in HeLa cells, leading to deficiency in the formation of autophagic structures and autophagic substrate degradation.

Chemical Structure

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DC-LC3in-D5
CAS# unknown
Instruction

Theoretical Analysis

Hodoodo Cat#: H465944
Name: DC-LC3in-D5
CAS#: unknown
Chemical Formula: C19H22Cl2N2O3
Exact Mass: 396.10
Molecular Weight: 397.296
Elemental Analysis: C, 57.44; H, 5.58; Cl, 17.85; N, 7.05; O, 12.08

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: DC-LC3in-D5; DCLC3in-D5; DC LC3in-D5; DC-LC3inD5; DC-LC3in D5; DCLC3inD5; DC LC3in D5;

IUPAC/Chemical Name: 5-(2,3-dichlorophenyl)-2-(((2-morpholinoethyl)amino)methylene)cyclohexane-1,3-dione

InChi Key: QWRGQCLNVZLPJO-QINSGFPZSA-N

InChi Code: InChI=1S/C19H22Cl2N2O3/c20-16-3-1-2-14(19(16)21)13-10-17(24)15(18(25)11-13)12-22-4-5-23-6-8-26-9-7-23/h1-3,12-13,22H,4-11H2/b15-12-

SMILES Code: O=C1/C(C(CC(C2=CC=CC(Cl)=C2Cl)C1)=O)=C/NCCN3CCOCC3

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 397.30 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Fan S, Yue L, Wan W, Zhang Y, Zhang B, Otomo C, Li Q, Lin T, Hu J, Xu P, Zhu M, Tao H, Chen Z, Li L, Ding H, Yao Z, Lu J, Wen Y, Zhang N, Tan M, Chen K, Xie Y, Otomo T, Zhou B, Jiang H, Dang Y, Luo C. Inhibition of Autophagy by a Small Molecule through Covalent Modification of the LC3 Protein. Angew Chem Int Ed Engl. 2021 Dec 6;60(50):26105-26114. doi: 10.1002/anie.202109464. Epub 2021 Nov 5. PMID: 34590387; PMCID: PMC8845813.