WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H466027
CAS#: unknown
Description: RTI-97 is a novel potent and selective KOR antagonist.
Hodoodo Cat#: H466027
Name: RTI-97
CAS#: unknown
Chemical Formula: C29H41N3O3
Exact Mass: 479.31
Molecular Weight: 479.665
Elemental Analysis: C, 72.62; H, 8.62; N, 8.76; O, 10.01
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Synonym: RTI-97; RTI 97; RTI97;
IUPAC/Chemical Name: (R)-7-hydroxy-N-((S)-1-((3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl)-3-methylbutan-2-yl)-2-methyl-1,2,3,4-tetrahydroisoquinoline-3-carboxamide
InChi Key: OHIFKDNMHSXJFA-XAOJMSMDSA-N
InChi Code: InChI=1S/C29H41N3O3/c1-19(2)26(30-28(35)27-14-21-9-10-25(34)13-22(21)17-31(27)5)18-32-12-11-29(4,20(3)16-32)23-7-6-8-24(33)15-23/h6-10,13,15,19-20,26-27,33-34H,11-12,14,16-18H2,1-5H3,(H,30,35)/t20-,26+,27+,29+/m0/s1
SMILES Code: O=C([C@@H]1N(C)CC2=C(C=CC(O)=C2)C1)N[C@@H](C(C)C)CN3C[C@H](C)[C@](C)(C4=CC=CC(O)=C4)CC3
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 479.67 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Fillesoye F, Ibazizène M, Marie N, Noble F, Perrio C. Evaluation of Specific Binding of [11C]RTI-97 to Kappa Opioid Receptor by Autoradiography and PET Imaging in Rat. ACS Med Chem Lett. 2021 Oct 19;12(11):1739-1744. doi: 10.1021/acsmedchemlett.1c00369. PMID: 34795862; PMCID: PMC8591749.
2: Owens SM, Pollard GT, Howard JL, Fennell TR, Snyder RW, Carroll FI. Pharmacodynamic Relationships between Duration of Action of JDTic-like Kappa- Opioid Receptor Antagonists and Their Brain and Plasma Pharmacokinetics in Rats. ACS Chem Neurosci. 2016 Dec 21;7(12):1737-1745. doi: 10.1021/acschemneuro.6b00249. Epub 2016 Oct 4. PMID: 27700049; PMCID: PMC6532972.
