WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H577815
CAS#: 875430-26-5
Description: Muraglitazar glucuronide is a Peroxime Proliferator Activated (PPAR) Agonist that has glucose- and lipid-lowering activities.
Hodoodo Cat#: H577815
Name: Muraglitazar glucuronide
CAS#: 875430-26-5
Chemical Formula: C35H36N2O13
Exact Mass: 692.22
Molecular Weight: 692.670
Elemental Analysis: C, 60.69; H, 5.24; N, 4.04; O, 30.03
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Synonym: Muraglitazar glucuronide; Muraglitazar metabolite M13
IUPAC/Chemical Name: (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-((N-((4-methoxyphenoxy)carbonyl)-N-(4-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)benzyl)glycyl)oxy)tetrahydro-2H-pyran-2-carboxylic acid
InChi Key: VLMNHAOSAKQBJM-WKRHDJAJSA-N
InChi Code: 1S/C35H36N2O13/c1-20-26(36-32(47-20)22-6-4-3-5-7-22)16-17-46-24-10-8-21(9-11-24)18-37(35(44)48-25-14-12-23(45-2)13-15-25)19-27(38)49-34-30(41)28(39)29(40)31(50-34)33(42)43/h3-15,28-31,34,39-41H,16-19H2,1-2H3,(H,42,43)/t28-,29-,30+,31-,34+/m0/s1
SMILES Code: COc1ccc(OC(=O)N(CC(=O)O[C@@H]2O[C@@H]([C@@H](O)[C@H](O)[C@H]2O)C(=O)O)Cc3ccc(OCCc4nc(oc4C)c5ccccc5)cc3)cc1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 692.67 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Coletta DK, Fernandez M, Cersosimo E, Gastaldelli A, Musi N, DeFronzo RA. The effect of muraglitazar on adiponectin signalling, mitochondrial function and fat oxidation genes in human skeletal muscle in vivo. Diabet Med. 2015 May;32(5):657-64. doi: 10.1111/dme.12664. Epub 2015 Jan 7. PubMed PMID: 25484175.
2: Paukkeri EL, Leppänen T, Lindholm M, Yam MF, Asmawi MZ, Kolmonen A, Aulaskari PH, Moilanen E. Anti-inflammatory properties of a dual PPARgamma/alpha agonist muraglitazar in in vitro and in vivo models. Arthritis Res Ther. 2013 Apr 17;15(2):R51. doi: 10.1186/ar4211. PubMed PMID: 23594962; PubMed Central PMCID: PMC4060226.
3: Fernandez M, Gastaldelli A, Triplitt C, Hardies J, Casolaro A, Petz R, Tantiwong P, Musi N, Cersosimo E, Ferrannini E, DeFronzo RA. Metabolic effects of muraglitazar in type 2 diabetic subjects. Diabetes Obes Metab. 2011 Oct;13(10):893-902. doi: 10.1111/j.1463-1326.2011.01429.x. PubMed PMID: 21615671.