WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H556675
CAS#: 1393748-80-5
Description: RY785 is a selective inhibitor of Kv2.1 voltage-gated potassium channels (IC50 = 0.05 µM) that does not affect Cav2 calcium channels.
Hodoodo Cat#: H556675
Name: RY785
CAS#: 1393748-80-5
Chemical Formula: C21H20N4O2S
Exact Mass: 392.13
Molecular Weight: 392.477
Elemental Analysis: C, 64.27; H, 5.14; N, 14.28; O, 8.15; S, 8.17
Synonym: RY785; RY-785; RY 785;
IUPAC/Chemical Name: 3-methoxy-α-methyl-N-[2-(4-thiazolyl)-1H-benzimidazol-6-yl]-benzenepropanamide
InChi Key: BRHVBJUDTWQELF-UHFFFAOYSA-N
InChi Code: InChI=1S/C21H20N4O2S/c1-13(8-14-4-3-5-16(9-14)27-2)21(26)23-15-6-7-17-18(10-15)25-20(24-17)19-11-28-12-22-19/h3-7,9-13H,8H2,1-2H3,(H,23,26)(H,24,25)
SMILES Code: O=C(NC1=CC=C2N=C(C3=CSC=N3)NC2=C1)C(C)CC4=CC=CC(OC)=C4
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 392.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
Herrington J, Solly K, Ratliff KS, Li N, Zhou YP, Howard A, Kiss L, Garcia ML, McManus OB, Deng Q, Desai R, Xiong Y, Kaczorowski GJ. Identification of novel and selective Kv2 channel inhibitors. Mol Pharmacol. 2011 Dec;80(6):959-64. doi: 10.1124/mol.111.074831. Epub 2011 Sep 26. PMID: 21948463.