WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H466132
CAS#: 127061-56-7 (potassium)
Description: EPC-K1 is a Vitamin E derivative, suppressing inflammation during hepatic ischemia-reperfusion injury and exerting hepatoprotective effects.
Hodoodo Cat#: H466132
Name: EPC-K1
CAS#: 127061-56-7 (potassium)
Chemical Formula: C35H56KO10P
Exact Mass: 706.32
Molecular Weight: 706.895
Elemental Analysis: C, 59.47; H, 7.99; K, 5.53; O, 22.63; P, 4.38
This product is not in stock, which may be available by custom synthesis.
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Synonym: EPC-K1; EPCK1; EPC K1; Potassium ascorbyl tocopheryl phosphate;
IUPAC/Chemical Name: potassium (R)-5-((S)-1,2-dihydroxyethyl)-4-hydroxy-2-oxo-2,5-dihydrofuran-3-yl ((R)-2,5,7,8-tetramethyl-2-((4R,8R)-4,8,12-trimethyltridecyl)chroman-6-yl) phosphate
InChi Key: VIHIKSJKXIMMLV-FZTHFCCHSA-M
InChi Code: InChI=1S/C35H57O10P.K/c1-21(2)12-9-13-22(3)14-10-15-23(4)16-11-18-35(8)19-17-27-26(7)30(24(5)25(6)31(27)43-35)44-46(40,41)45-33-29(38)32(28(37)20-36)42-34(33)39;/h21-23,28,32,36-38H,9-20H2,1-8H3,(H,40,41);/q;+1/p-1/t22-,23-,28+,32-,35-;/m1./s1
SMILES Code: O=P(OC1=C(O)[C@@H]([C@@H](O)CO)OC1=O)([O-])OC2=C(C)C(CC[C@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)O3)=C3C(C)=C2C.[K+]
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 706.90 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
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6: Chang WJ, Toledo-Pereyra LH. Importance of EPC-K1 in ischemia and reperfusion injury. J Surg Res. 2011 Jun 15;168(2):173-4. doi: 10.1016/j.jss.2010.06.027. Epub 2010 Sep 8. PMID: 20850788.
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15: Irie H, Kato T, Ikebe K, Tsuchida T, Oniki Y, Takagi K. Antioxidant effect of MCI-186, a new Free-Radical scavenger, on ischemia-reperfusion injury in a rat hindlimb amputation model. J Surg Res. 2004 Aug;120(2):312-9. doi: 10.1016/j.jss.2003.12.004. PMID: 15234228.
16: Kozuka M, Tsujimoto Y. Dentin is dissolved by high concentrations of L-ascorbic acid 2-[3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)- 2H-1-benzopyran-6-yl-hydrogen phosphate] potassium salt with or without hydrogen peroxide. Biol Pharm Bull. 2004 Jun;27(6):831-4. doi: 10.1248/bpb.27.831. PMID: 15187428.
17: Takayama H, Hamner CE, Caccitolo JA, Hisamochi K, Pearson PJ, Schaff HV. A novel antioxidant, EPC-K1, stimulates endothelial nitric oxide production and scavenges hydroxyl radicals. Circ J. 2003 Dec;67(12):1046-52. doi: 10.1253/circj.67.1046. PMID: 14639022.
18: Kato N, Yanaka K, Nagase S, Hirayama A, Nose T. The antioxidant EPC-K1 ameliorates brain injury by inhibiting lipid peroxidation in a rat model of transient focal cerebral ischaemia. Acta Neurochir (Wien). 2003 Jun;145(6):489-93; discussion 493. doi: 10.1007/s00701-003-0036-z. PMID: 12836074.
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20: Matsuo K, Mori S, Ijichi T, Nakajima K, Kokufu T, Ihara N. EPC-K1 reduces the expression of inducible nitric oxide synthase (iNOS) in delayed neuronal death (DND). Ann N Y Acad Sci. 2002 Nov;977:292-5. doi: 10.1111/j.1749-6632.2002.tb04828.x. PMID: 12480763.