WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H466139
CAS#: 15565-46-5
Description: XuBP is a potent inhibitor of ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco).
Hodoodo Cat#: H466139
Name: XuBP
CAS#: 15565-46-5
Chemical Formula: C5H12O11P2
Exact Mass: 309.99
Molecular Weight: 310.088
Elemental Analysis: C, 19.37; H, 3.90; O, 56.75; P, 19.98
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Synonym: XuBP; Xu BP; Xu-BP; Xylulose-1,5-Bisphosphate;
IUPAC/Chemical Name: (2R,3S)-2,3-dihydroxy-4-oxopentane-1,5-diyl bis(dihydrogen phosphate)
InChi Key: YAHZABJORDUQGO-WUJLRWPWSA-N
InChi Code: InChI=1S/C5H12O11P2/c6-3(1-15-17(9,10)11)5(8)4(7)2-16-18(12,13)14/h3,5-6,8H,1-2H2,(H2,9,10,11)(H2,12,13,14)/t3-,5+/m1/s1
SMILES Code: O=P(O)(OC[C@@H](O)[C@H](O)C(COP(O)(O)=O)=O)O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 310.09 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Bracher A, Sharma A, Starling-Windhof A, Hartl FU, Hayer-Hartl M. Degradation of potent Rubisco inhibitor by selective sugar phosphatase. Nat Plants. 2015 Jan 8;1:14002. doi: 10.1038/nplants.2014.2. PMID: 27246049.
2: Schrader SM, Kane HJ, Sharkey TD, von Caemmerer S. High temperature enhances inhibitor production but reduces fallover in tobacco Rubisco. Funct Plant Biol. 2006 Oct;33(10):921-929. doi: 10.1071/FP06059. PMID: 32689302.
3: Yokota A, Wadano A, Murayama H. Modeling of continuously and directly analyzed biphasic reaction courses of ribulose 1,5-bisphosphate carboxylase/oxygenase. J Biochem. 1996 Mar;119(3):487-99. doi: 10.1093/oxfordjournals.jbchem.a021268. PMID: 8830044.
4: Zhu G, Jensen RG. Fallover of Ribulose 1,5-Bisphosphate Carboxylase/Oxygenase Activity : Decarbamylation of Catalytic Sites Depends on pH. Plant Physiol. 1991 Dec;97(4):1354-8. doi: 10.1104/pp.97.4.1354. PMID: 16668556; PMCID: PMC1081171.
5: Zhu G, Jensen RG. Xylulose 1,5-Bisphosphate Synthesized by Ribulose 1,5-Bisphosphate Carboxylase/Oxygenase during Catalysis Binds to Decarbamylated Enzyme. Plant Physiol. 1991 Dec;97(4):1348-53. doi: 10.1104/pp.97.4.1348. PMID: 16668555; PMCID: PMC1081170