WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H466143
CAS#: unknown
Description: YS8 is a novel TICT-based fluorescent probe, inhibiting the formation of TICT state and producing a clear light-up fluorescent signal, discriminating HSA from other proteins including the bovine serum albumin (BSA).
Hodoodo Cat#: H466143
Name: YS8
CAS#: unknown
Chemical Formula: C36H28N2
Exact Mass: 488.23
Molecular Weight: 488.634
Elemental Analysis: C, 88.49; H, 5.78; N, 5.73
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Synonym: YS8; YS 8; YS-8;
IUPAC/Chemical Name: (E)-2-(4-(2-methylstyryl)phenyl)-1,4,5-triphenyl-1H-imidazole
InChi Key: DQGRTPFPVSZEES-DARPEHSRSA-N
InChi Code: InChI=1S/C36H28N2/c1-27-13-11-12-14-29(27)24-21-28-22-25-32(26-23-28)36-37-34(30-15-5-2-6-16-30)35(31-17-7-3-8-18-31)38(36)33-19-9-4-10-20-33/h2-26H,1H3/b24-21+
SMILES Code: CC1=CC=CC=C1/C=C/C2=CC=C(C3=NC(C4=CC=CC=C4)=C(C5=CC=CC=C5)N3C6=CC=CC=C6)C=C2
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 488.63 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Luo Y, Yu QQ, Gao JJ, Lang XX, Li HY, Yu XF, Qi XY, Wang MQ. Design, synthesis and mechanistic studies of a TICT based fluorogenic probe for lighting up protein HSA. Bioorg Med Chem Lett. 2021 Dec 1;53:128438. doi: 10.1016/j.bmcl.2021.128438. Epub 2021 Nov 2. PMID: 34740774.
2: Yuan B, Zhu W, Hung I, Gan Z, Aitken B, Sen S. Structure and Chemical Order in S-Se Binary Glasses. J Phys Chem B. 2018 Dec 20;122(50):12219-12226. doi: 10.1021/acs.jpcb.8b10052. Epub 2018 Dec 11. PMID: 30485101.
3: Tang H, Shi X, Wang X, Hao H, Zhang XM, Zhang LP. Environmental Controls Over Actinobacteria Communities in Ecological Sensitive Yanshan Mountains Zone. Front Microbiol. 2016 Mar 22;7:343. doi: 10.3389/fmicb.2016.00343. PMID: 27047461; PMCID: PMC4801888.
4: Seo MJ, Lee BS, Pyun YR, Park H. Isolation and characterization of N-acylhomoserine lactonase from the thermophilic bacterium, Geobacillus caldoxylosilyticus YS-8. Biosci Biotechnol Biochem. 2011;75(9):1789-95. doi: 10.1271/bbb.110322. Epub 2011 Sep 7. PMID: 21897031.
5: Ignatovich O, Cooper M, Kulesza HM, Beggs JD. Cloning and characterisation of the gene encoding the ribosomal protein S5 (also known as rp14, S2, YS8) of Saccharomyces cerevisiae. Nucleic Acids Res. 1995 Nov 25;23(22):4616-9. doi: 10.1093/nar/23.22.4616. PMID: 8524651; PMCID: PMC307434.
6: Wen BH, Yu SR, Yu GQ, Li QJ, Zhang X. Analysis of proteins and lipopolysaccharides from Chinese isolates of Coxiella burnetii with monoclonal antibodies. Acta Virol. 1991 Nov;35(6):538-44. PMID: 1687637.
7: Day ED, Hashim GA, Potter NT, Lazarus KJ. Immunochemical analysis of Lewis rat antisera to the synthetic encephalitogenic peptide S49. Neurochem Res. 1985 Dec;10(12):1587-603. doi: 10.1007/BF00988601. PMID: 2418380.
8: Otaka E, Higo K, Itoh T. Yeast ribosomal proteins. VIII. Isolation of two proteins and sequence characterization of twenty-four proteins from cytoplasmic ribosomes. Mol Gen Genet. 1984;195(3):544-6. doi: 10.1007/BF00341461. PMID: 18782943.
9: Otaka E, Higo K, Osawa S. Isolation of seventeen proteins and amino-terminal amino acid sequences of eight proteins from cytoplasmic ribosomes of yeast. Biochemistry. 1982 Sep 14;21(19):4545-50. doi: 10.1021/bi00262a005. PMID: 6814480.