WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H466183
CAS#: unknown
Description: R-STU104 is an potent PPI inhibitor (TAK1−MKK3 Protein−Protein Interaction (PPI) Inhibitor) for the Treatment of Ulcerative Colitis through Modulating TNF‑α Production. (R)-STU104 exhibited the most potent inhibitory activity on TNF-α production, which suppressed the TAK1/MKK3/p38/MnK1/MK2/elF4E signal pathways through binding with MKK3 and disrupting the TAK1 phosphorylating MKK3. As a result, (R)-STU104 demonstrated remarkable dose−effect relationships on both acute and chronic mouse UC models.
Hodoodo Cat#: H466183
Name: R-STU104
CAS#: unknown
Chemical Formula: C18H18O4
Exact Mass: 298.12
Molecular Weight: 298.338
Elemental Analysis: C, 72.47; H, 6.08; O, 21.45
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Synonym: R-STU104; R STU104; RSTU104;
IUPAC/Chemical Name: (R)-4,6-dimethoxy-3-(4-methoxyphenyl)-2,3-dihydro-1H-inden-1-one
InChi Key: OYJBHGSSAJNKJF-CQSZACIVSA-N
InChi Code: InChI=1S/C18H18O4/c1-20-12-6-4-11(5-7-12)14-10-16(19)15-8-13(21-2)9-17(22-3)18(14)15/h4-9,14H,10H2,1-3H3/t14-/m1/s1
SMILES Code: COC(C=C1)=CC=C1[C@@H](C2)C3=C(OC)C=C(OC)C=C3C2=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 298.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Tang ML, Li H, Ning JF, Shen X, Sun X. Discovery of First-in-Class TAK1-MKK3 Protein-Protein Interaction (PPI) Inhibitor (R)-STU104 for the Treatment of Ulcerative Colitis through Modulating TNF-α Production. J Med Chem. 2022 Apr 20. doi: 10.1021/acs.jmedchem.1c02198. Epub ahead of print. PMID: 35442672.