WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H578072
CAS#: 6153-64-6
Description: Oxytetracycline dihydrate is a tetracycline derivative with antimicrobial activity.
Hodoodo Cat#: H578072
Name: Oxytetracycline dihydrate
CAS#: 6153-64-6
Chemical Formula: C22H28N2O11
Exact Mass: 496.17
Molecular Weight: 496.470
Elemental Analysis: C, 53.22; H, 5.68; N, 5.64; O, 35.45
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.
Synonym: Neo-oxy 50/50; OXTC; Oxytetracycline dihydrate; Terramycin
IUPAC/Chemical Name: 2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,6,10,12,12a-hexahydroxy-6-methyl-1,11-dioxo-, dihydrate, (4S,4aR,5S,5aR,6S,12aS)-
InChi Key: SRRPEXWCHWWJOC-JEKSYDDFSA-N
InChi Code: InChI=1S/C22H24N2O9.2H2O/c1-21(32)7-5-4-6-8(25)9(7)15(26)10-12(21)17(28)13-14(24(2)3)16(27)11(20(23)31)19(30)22(13,33)18(10)29;;/h4-6,12-14,17,25,27-29,32-33H,1-3H3,(H2,23,31);2*1H2/t12-,13-,14+,17+,21-,22+;;/m1../s1
SMILES Code: O.O.CN(C)[C@H]1[C@@H]2[C@@H](O)[C@H]3C(=C(O)[C@]2(O)C(=O)C(=C1O)C(=O)N)C(=O)c4c(O)cccc4[C@@]3(C)O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 496.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Gao C, Liu Z, Chen J, Yan Z. A novel fluorescent assay for oxytetracycline hydrochloride based on fluorescence quenching of water-soluble CdTe nanocrystals. Luminescence. 2013 May-Jun;28(3):378-83. doi: 10.1002/bio.2393. Epub 2012 Jun 19. PubMed PMID: 22715152.
2: López-Jornet P, Camacho-Alonso F, Martinez-Canovas A, Sidrach-Cardona M. Topical 1% oxytetracycline hydrochloride versus placebo in oral mucosa biopsy. Dermatol Surg. 2012 Jul;38(7Pt 1):1054-8. doi: 10.1111/j.1524-4725.2012.02399.x. Epub 2012 Mar 27. PubMed PMID: 22455385.
3: Morales-Nin B, Grau A, Pérez-Mayol S, Pastor E, Palmer M. Oxytetracycline hydrochloride vital labelling revisited: the case of Dicentrarchus labrax and Diplodus puntazzo. J Fish Biol. 2011 Mar;78(3):762-82. doi: 10.1111/j.1095-8649.2010.02887.x. PubMed PMID: 21366571.
4: Berry SL, Read DH, Walker RL, Famula TR. Clinical, histologic, and bacteriologic findings in dairy cows with digital dermatitis (footwarts) one month after topical treatment with lincomycin hydrochloride or oxytetracycline hydrochloride. J Am Vet Med Assoc. 2010 Sep 1;237(5):555-60. doi: 10.2460/javma.237.5.555. PubMed PMID: 20807134.
5: Kim H, Lee BJ, Sah H. Reverse micelle-based microencapsulation of oxytetracycline hydrochloride into poly-d,l-lactide-co-glycolide microspheres. Drug Deliv. 2007 Feb;14(2):95-9. PubMed PMID: 17364873.
6: Osofsky A, Tell LA, Kass PH, Wetzlich SE, Nugent-Deal J, Craigmill AL. Investigation of Japanese quail (Coturnix japonica) as a pharmacokinetic model for cockatiels (Nymphicus hollandicus) and Poicephalus parrots via comparison of the pharmacokinetics of a single intravenous injection of oxytetracycline hydrochloride. J Vet Pharmacol Ther. 2005 Dec;28(6):505-13. PubMed PMID: 16343282.
7: Sun XX, Zhang X, Aboul-Enein HY. Construction and characterization of potentiometric sensor for the determination of oxytetracycline hydrochloride. Farmaco. 2004 Apr;59(4):307-14. PubMed PMID: 15081348.
8: Liebenberg W, de Villiers MM, Wurster DE, Swanepoel E, Dekker TG, Lötter AP. The effect of polymorphism on powder compaction and dissolution properties of chemically equivalent oxytetracycline hydrochloride powders. Drug Dev Ind Pharm. 1999 Sep;25(9):1027-33. PubMed PMID: 10518242.
9: Elsheikh HA, Osman Intisar AM, Eltayeb IB, Salam Abdullah A. Effect of dehydration on the pharmacokinetics of oxytetracycline hydrochloride administered intravenously in goats (Capra hircus). Gen Pharmacol. 1998 Sep;31(3):455-8. PubMed PMID: 9703219.
10: Izer K, Török I, Pintér-Magyar G. Stability of oxytetracycline hydrochloride in eye-drops, prepared in pharmacies. Acta Pharm Hung. 1994 Mar;64(2):63-6. PubMed PMID: 8017210.
11: Faktor JH, Frenkel Y, Mashiach S, Serr DM. Intra-amniotic injection of oxytetracycline hydrochloride for termination of mid-trimester pregnancy. Gynecol Obstet Invest. 1988;26(3):177-80. PubMed PMID: 3240887.
12: Mesiha MS, Aboutaleb AE. The prolonged release of oxytetracycline hydrochloride from ethylcellulose microcapsules. Pharmazie. 1982 Jul;37(7):493-5. PubMed PMID: 7134255.
13: Mueller-Brennecke DL, Reed SJ, Waisner DL. Turbidimetric microbiological determination of oxytetracycline hydrochloride in finished feeds and a feed premix: collaborative study. J Assoc Off Anal Chem. 1980 Sep;63(5):1038-43. PubMed PMID: 7410294.
14: Marković D, Kezele D, Kuburović D, Zivanov-Stankić D. [The action of oxytetracycline hydrochloride under in vitro conditions]. Osterr Z Stomatol. 1978 Jun;75(6):225-8. German. PubMed PMID: 283364.
15: Marković D, Zivanov-Stakić D, Radović Z, Kezele D. [Oxytetracycline and oxytetracycline hydrochloride as components of tooth dentinal calcium]. Stomatol Glas Srb. 1977 Aug-Oct;24(4):239-43. Croatian. PubMed PMID: 288214.
16: de Jong MF, Oosterwoud RA. Treatment with oxytetracycline hydrochloride in the prevention of atrophic rhinitis in baby pigs. Tijdschr Diergeneeskd. 1977 Feb 15;102(4):266-73. Dutch. PubMed PMID: 835133.
17: Markovic D, Sćepan V. [Effects of EDTA and oxytetracycline hydrochloride and their complexes with calcium on microorganisms isolated from the root canals of diseased teeth]. Stomatol Vjesn. 1977;6(3-4):17-9. Croatian. PubMed PMID: 116396.
18: Saavedra FE, Belikov VG, Soloveĭ NV. [Spectrophotometric determination of oxytetracycline hydrochloride]. Farmatsiia. 1976 Jan-Feb;25(1):78-9. Russian. PubMed PMID: 1254013.
19: Renshaw HW, Magonigle RA, Eckblad WP, Frank FW. Immunity to bovine anaplasmosis after elimination of the carrier status with oxytetracycline hydrochloride. Proc Annu Meet U S Anim Health Assoc. 1976;(80):79-88. PubMed PMID: 1078098.
20: Lal OP, Teotia TP. Influence of nine surfactants on the activity of oxytetracycline hydrochloride against Lipaphis erysimi Kalt. J Antibiot (Tokyo). 1975 Dec;28(12):993-6. PubMed PMID: 1206011.
