WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H466240
CAS#: 1206480-93-4
Description: EM 163 is a TIR-TIR interaction inhibitor, that is a TIR (Toll/ interleukin-1 receptor) domain peptidomimetic of MyD88 protein. EM 163 targets TIR domains in IL-1 receptors blocking the interaction with MyD88. EM 163 inhibits staphylococcal enterotoxin B (SEB)-induced inflammatory cytokine production in vivo. EM 163 protects mice from SEB shock-induced death. In rat hippocampal neurons in vitro, EM 163 blocks the activation of p38 and the inhibitory effects of IL-1β on protein synthesis triggered by chemically-induced long-term potentiation (LTP).
Hodoodo Cat#: H466240
Name: EM 163
CAS#: 1206480-93-4
Chemical Formula: C44H60IN5O4
Exact Mass: 849.37
Molecular Weight: 849.900
Elemental Analysis: C, 62.18; H, 7.12; I, 14.93; N, 8.24; O, 7.53
Synonym: EM 163; EM-163; EM163;
IUPAC/Chemical Name: 1-methyl-2,5-bis(((S)-3-methyl-1-oxo-1-(pyrrolidin-1-yl)butan-2-yl)(3-phenylpropyl)carbamoyl)pyridin-1-ium iodide
InChi Key: WJCJDZIXEVJIKZ-OFUZFLEOSA-M
InChi Code: InChI=1S/C44H60N5O4.HI/c1-33(2)39(43(52)46-26-12-13-27-46)48(30-16-22-35-18-8-6-9-19-35)41(50)37-24-25-38(45(5)32-37)42(51)49(31-17-23-36-20-10-7-11-21-36)40(34(3)4)44(53)47-28-14-15-29-47;/h6-11,18-21,24-25,32-34,39-40H,12-17,22-23,26-31H2,1-5H3;1H/q+1;/p-1/t39-,40-;/m0./s1
SMILES Code: CC(C)[C@H](N(CCCC1=CC=CC=C1)C(C2=C[N+](C)=C(C=C2)C(N(CCCC3=CC=CC=C3)[C@@H](C(C)C)C(N4CCCC4)=O)=O)=O)C(N5CCCC5)=O.[I-]
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 85.0 | 100.00 |
The following data is based on the product molecular weight 849.90 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Zhang Q, Yang B, Li F, Liu M, Lin S, Wang J, Xue Y, Zhu H, Sun W, Hu Z, Zhang Y. Mycophenolic Acid Derivatives with Immunosuppressive Activity from the Coral- Derived Fungus Penicillium bialowiezense. Mar Drugs. 2018 Jul 7;16(7):230. doi: 10.3390/md16070230. PMID: 29986508; PMCID: PMC6070797.
2: Lucas K, Maes M. Role of the Toll Like receptor (TLR) radical cycle in chronic inflammation: possible treatments targeting the TLR4 pathway. Mol Neurobiol. 2013 Aug;48(1):190-204. doi: 10.1007/s12035-013-8425-7. Epub 2013 Feb 26. PMID: 23436141; PMCID: PMC7091222.
3: Kissner TL, Ruthel G, Alam S, Mann E, Ajami D, Rebek M, Larkin E, Fernandez S, Ulrich RG, Ping S, Waugh DS, Rebek J Jr, Saikh KU. Therapeutic inhibition of pro-inflammatory signaling and toxicity to staphylococcal enterotoxin B by a synthetic dimeric BB-loop mimetic of MyD88. PLoS One. 2012;7(7):e40773. doi: 10.1371/journal.pone.0040773. Epub 2012 Jul 27. PMID: 22848400; PMCID: PMC3407147.
