Ergonovine tartrate

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H578087

CAS#: 129-50-0

Description: Ergonovine tartrate is an ergot alkaloid with uterine and vascular smooth muscle contractility properties.

Chemical Structure

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Ergonovine tartrate
CAS# 129-50-0
Instruction

Theoretical Analysis

Hodoodo Cat#: H578087
Name: Ergonovine tartrate
CAS#: 129-50-0
Chemical Formula: C42H52N6O10
Exact Mass: 800.37
Molecular Weight: 800.910
Elemental Analysis: C, 62.99; H, 6.54; N, 10.49; O, 19.98

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Basergin; Ergobasine tartrate; Ergonovine tartrate; Neofemergen; Neofermergen

IUPAC/Chemical Name: (6aR,9R)-N-((S)-1-hydroxypropan-2-yl)-7-methyl-4,6,6a,7,8,9-hexahydroindolo[4,3-fg]quinoline-9-carboxamide hemi((2R,3R)-2,3-dihydroxysuccinate)

InChi Key: LCWZQWWOZZUXTM-TVOBTDOISA-N

InChi Code: InChI=1S/2C19H23N3O2.C4H6O6/c2*1-11(10-23)21-19(24)13-6-15-14-4-3-5-16-18(14)12(8-20-16)7-17(15)22(2)9-13;5-1(3(7)8)2(6)4(9)10/h2*3-6,8,11,13,17,20,23H,7,9-10H2,1-2H3,(H,21,24);1-2,5-6H,(H,7,8)(H,9,10)/t2*11-,13+,17+;1-,2-/m001/s1

SMILES Code: C[C@@H](CO)NC(=O)[C@H]1CN(C)[C@@H]2Cc3c[nH]c4cccc(C2=C1)c34.C[C@@H](CO)NC(=O)[C@H]5CN(C)[C@@H]6Cc7c[nH]c8cccc(C6=C5)c78.O[C@H]([C@@H](O)C(=O)O)C(=O)O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 800.91 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Maclean AB. Ergometrine. J Obstet Gynaecol. 2005 Jan;25(1):1-2. doi: 10.1080/01443610400023429. PMID: 16147681.

2: Heupler FA Jr, Proudfit WL, Razavi M, Shirey EK, Greenstreet R, Sheldon WC. Ergonovine maleate provocative test for coronary arterial spasm. Am J Cardiol. 1978 Apr;41(4):631-40. doi: 10.1016/0002-9149(78)90810-x. PMID: 645566.

3: Sueda S, Kohno H, Ochi T, Uraoka T, Tsunemitsu K. Overview of the pharmacological spasm provocation test: Comparisons between acetylcholine and ergonovine. J Cardiol. 2017 Jan;69(1):57-65. doi: 10.1016/j.jjcc.2016.09.012. Epub 2016 Nov 15. PMID: 27856130.

4: Cheng T. Ergonovine maleate and beta-blockers for Prinzmetal's angina. Circulation. 2001 Feb 13;103(6):E30. doi: 10.1161/01.cir.103.6.e30. PMID: 11171807.

5: Raskin NH, Prusiner S. Carotidynia. Neurology. 1977 Jan;27(1):43-6. doi: 10.1212/wnl.27.1.43. PMID: 556819.

6: Harding MB, Leithe ME, Mark DB, Nelson CL, Harrison JK, Hermiller JB, Davidson CJ, Pryor DB, Bashore TM. Ergonovine maleate testing during cardiac catheterization: a 10-year perspective in 3,447 patients without significant coronary artery disease or Prinzmetal's variant angina. J Am Coll Cardiol. 1992 Jul;20(1):107-11. doi: 10.1016/0735-1097(92)90145-d. Erratum in: J Am Coll Cardiol 1993 Mar 1;21(3):848. PMID: 1607510.

7: Shane JM, Naftolin F. Effect of ergonovine maleate on puerperal prolactin. Am J Obstet Gynecol. 1974 Sep;120(1):129-31. doi: 10.1016/0002-9378(74)90190-2. PMID: 4602154.

8: Sakamoto Y, Krzanowski JJ, Lockey RF, Duncan R, Polson JB, Szentivanyi A. The mechanism of ergonovine-induced airway smooth muscle contraction. J Allergy Clin Immunol. 1986 Feb;77(2):354-64. doi: 10.1016/s0091-6749(86)80118-x. PMID: 3944386.

9: Moir DD. Ergometrine. Br Med J. 1970 Feb 28;1(5695):563-4. doi: 10.1136/bmj.1.5695.563-c. PMID: 5435196; PMCID: PMC1699505.

10: Albanese C, Rea A. Utilitá e rischi del test con ergonovina maleato in cardiologia [Usefulness and risks of the ergonovine maleate test in cardiology]. Recenti Prog Med. 1981 Sep;71(3):331-3. Italian. PMID: 7034085.