WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H471172
CAS#: 145849-32-7
Description: DPPS is a form of phosphatidylserine (PS), an anionic phospholipid.
Hodoodo Cat#: H471172
Name: DPPS
CAS#: 145849-32-7
Chemical Formula: C38H73NNaO10P
Exact Mass: 0.00
Molecular Weight: 757.960
Elemental Analysis: C, 60.22; H, 9.71; N, 1.85; Na, 3.03; O, 21.11; P, 4.09
Synonym: DPPS; 1,2-DPPS; PS 16:0/16:0; 1,2-Dipalmitoyl-sn-glycero-3-phospho-L-serine
IUPAC/Chemical Name: (2S,8R)-2-amino-5-hydroxy-11-oxo-8-[(1-oxohexadecyl)oxy]-4,6,10-trioxa-5-phosphahexacosanoic acid, 5-oxide, monosodium salt
InChi Key: GTLXLANTBWYXGW-CEGNZRHUSA-M
InChi Code: InChI=1S/C38H74NO10P.Na/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-36(40)46-31-34(32-47-50(44,45)48-33-35(39)38(42)43)49-37(41)30-28-26-24-22-20-18-16-14-12-10-8-6-4-2;/h34-35H,3-33,39H2,1-2H3,(H,42,43)(H,44,45);/q;+1/p-1/t34-,35+;/m1./s1
SMILES Code: O=C(OC[C@H](COP(OC[C@@H](C([O-])=O)[NH3+])([O-])=O)OC(CCCCCCCCCCCCCCC)=O)CCCCCCCCCCCCCCC.[Na+]
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in chloroform
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in chloroform
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
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The following data is based on the product molecular weight 757.96 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1. Brown KL, Conboy JC. Lipid flip-flop in binary membranes composed of phosphatidylserine and phosphatidylcholine. J Phys Chem B. 2013 Dec 5;117(48):15041-50. doi: 10.1021/jp409672q. Epub 2013 Nov 22. PMID: 24200035.
2. Marr JM, Li F, Petlick AR, Schafer R, Hwang CT, Chabot A, Ruggiero ST, Tanner CE, Schultz ZD. The role of lateral tension in calcium-induced DPPS vesicle rupture. Langmuir. 2012 Aug 14;28(32):11874-80. doi: 10.1021/la301976s. Epub 2012 Jul 30. PMID: 22799521; PMCID: PMC3422639.
3. Ding Y , Chow SH , Liu GS , Wang B , Lin TW , Hsu HY , Duff AP , Le Brun AP , Shen HH . Annexin V-containing cubosomes for targeted early detection of apoptosis in degenerative retinal tissue. J Mater Chem B. 2018 Dec 14;6(46):7652-7661. doi: 10.1039/c8tb02465k. Epub 2018 Nov 5. PMID: 32254887.
