WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H208004
CAS#: N/A
Description: UPG-83 is a novel potent antagonist of the Urotensin-II (UT) Receptor
Hodoodo Cat#: H208004
Name: UPG-83
CAS#: N/A
Chemical Formula: C53H67N11O11S2
Exact Mass: 1,097.45
Molecular Weight: 1,098.305
Elemental Analysis: C, 57.96; H, 6.15; N, 14.03; O, 16.02; S, 5.84
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Synonym: UPG-83; UPG83; UPG 83
IUPAC/Chemical Name: (S)-4-(((4R,7S,10S,13S,16S,19S)-13-((1H-indol-3-yl)methyl)-10-(4-aminobutyl)-16-benzyl-4-(((S)-1-carboxy-2-methylpropyl)carbamoyl)-7-(4-cyanobenzyl)-17,20,20-trimethyl-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosan-19-yl)amino)-3-amino-4-oxobutanoic acid
InChi Key: KNXNDPUPURVVGP-LBKVYCCMSA-N
InChi Code: InChI=1S/C54H69N11O11S2/c1-30(2)44(53(75)76)63-50(72)41-29-77-78-54(3,4)45(64-46(68)36(57)26-43(66)67)52(74)65(5)42(24-31-13-7-6-8-14-31)51(73)61-40(25-34-28-58-37-16-10-9-15-35(34)37)49(71)59-38(17-11-12-22-55)47(69)60-39(48(70)62-41)23-32-18-20-33(27-56)21-19-32/h6-10,13-16,18-21,28,30,36,38-42,44-45,58H,11-12,17,22-26,29,55,57H2,1-5H3,(H,59,71)(H,60,69)(H,61,73)(H,62,70)(H,63,72)(H,64,68)(H,66,67)(H,75,76)/t36-,38-,39-,40-,41-,42-,44-,45-/m0/s1
SMILES Code: O=C(N[C@@H](CC1=CNC2=C1C=CC=C2)C(N[C@H](C(N[C@H](C(N[C@@H](CSSC(C)([C@H](C(N3C)=O)NC([C@@H](N)CC(O)=O)=O)C)C(N[C@@H](C(C)C)C(O)=O)=O)=O)CC4=CC=C(C#N)C=C4)=O)CCCCN)=O)[C@@H]3CC5=CC=CC=C5
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 1,098.31 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1. Carotenuto A, Auriemma L, Merlino F, Yousif AM, Marasco D, Limatola A, Campiglia P, Gomez-Monterrey I, Santicioli P, Meini S, Maggi CA, Novellino E, Grieco P. Lead optimization of P5U and urantide: discovery of novel potent ligands at the urotensin-II receptor. J Med Chem. 2014 Jul 24;57(14):5965-74. doi: 10.1021/jm500218x. Epub 2014 Jul 10. PMID: 24992374.