WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H208043
CAS#: N/A
Description: ZB-R-55 is a Potent and Selective RIPK1 Inhibitor. ZB-R-55 targets Dual-Pockets for the Treatment of Systemic Inflammatory Response Syndrome and Sepsis. ZB-R-55 is about 10-fold more potent than GSK2982772, and exhibits excellent kinase selectivity, good oral pharmacokinetics and good therapeutic effects in the LPS-induced sepsis model, suggesting that compound ZB-R-55 is a highly promising preclinical candidate.
Hodoodo Cat#: H208043
Name: ZB-R-55
CAS#: N/A
Chemical Formula: C25H23N5O3
Exact Mass: 441.18
Molecular Weight: 441.490
Elemental Analysis: C, 68.01; H, 5.25; N, 15.86; O, 10.87
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Synonym: ZB-R-55; ZB-R55; ZB-R 55; ZBR-55; ZBR55; ZBR 55;
IUPAC/Chemical Name: (S)-5-benzyl-N-(7-(cyclopropylethynyl)-5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]oxazepin-3-yl)-4H-1,2,4-triazole-3-carboxamide
InChi Key: QDIMLDKKJUQINI-IBGZPJMESA-N
InChi Code: InChI=1S/C25H23N5O3/c1-30-20-13-18(10-9-16-7-8-16)11-12-21(20)33-15-19(25(30)32)26-24(31)23-27-22(28-29-23)14-17-5-3-2-4-6-17/h2-6,11-13,16,19H,7-8,14-15H2,1H3,(H,26,31)(H,27,28,29)/t19-/m0/s1
SMILES Code: CN(C1=CC(C#CC2CC2)=CC=C1OC[C@@H]3NC(C4=NN=C(CC5=CC=CC=C5)N4)=O)C3=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 441.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1. Yang X, Lu H, Xie H, Zhang B, Nie T, Fan C, Yang T, Xu Y, Su H, Tang W, Zhou B. Potent and Selective RIPK1 Inhibitors Targeting Dual-Pockets for the Treatment of Systemic Inflammatory Response Syndrome and Sepsis. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202114922. doi: 10.1002/anie.202114922. Epub 2021 Dec 16. PMID: 34851543.