WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H466250
CAS#: 2820336-67-0
Description: JBJ-09-063 is an allosteric mutant-EGFR inhibitor.
Hodoodo Cat#: H466250
Name: JBJ-09-063
CAS#: 2820336-67-0
Chemical Formula: C31H29FN4O3S
Exact Mass: 556.19
Molecular Weight: 556.656
Elemental Analysis: C, 66.89; H, 5.25; F, 3.41; N, 10.07; O, 8.62; S, 5.76
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Synonym: JBJ-09-063; JBJ09-063; JBJ 09-063; JBJ-09063; JBJ-09 063; JBJ09063; JBJ 09 063;
IUPAC/Chemical Name: 2-(5-fluoro-2-hydroxyphenyl)-2-(6-(4-(1-methylpiperidin-4-yl)phenyl)-1-oxoisoindolin-2-yl)-N-(thiazol-2-yl)acetamide
InChi Key: SYTVDTWRIZNVEW-UHFFFAOYSA-N
InChi Code: InChI=1S/C31H29FN4O3S/c1-35-13-10-21(11-14-35)19-2-4-20(5-3-19)22-6-7-23-18-36(30(39)25(23)16-22)28(26-17-24(32)8-9-27(26)37)29(38)34-31-33-12-15-40-31/h2-9,12,15-17,21,28,37H,10-11,13-14,18H2,1H3,(H,33,34,38)
SMILES Code: OC1=CC=C(F)C=C1C(N2CC(C=CC(C3=CC=C(C4CCN(C)CC4)C=C3)=C5)=C5C2=O)C(NC6=NC=CS6)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 556.66 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: To C, Beyett TS, Jang J, Feng WW, Bahcall M, Haikala HM, Shin BH, Heppner DE, Rana JK, Leeper BA, Soroko KM, Poitras MJ, Gokhale PC, Kobayashi Y, Wahid K, Kurppa KJ, Gero TW, Cameron MD, Ogino A, Mushajiang M, Xu C, Zhang Y, Scott DA, Eck MJ, Gray NS, Jänne PA. An allosteric inhibitor against the therapy-resistant mutant forms of EGFR in non-small cell lung cancer. Nat Cancer. 2022 Apr;3(4):402-417. doi: 10.1038/s43018-022-00351-8. Epub 2022 Apr 14. PMID: 35422503.