ELOVL1 inhibitor 22

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H208065

CAS#: N/A

Description: ELOVL1 inhibitor 22 is a novel, orally bioavailable pyrimidine ether-based inhibitor.

Chemical Structure

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ELOVL1 inhibitor 22
CAS# N/A
Instruction

Theoretical Analysis

Hodoodo Cat#: H208065
Name: ELOVL1 inhibitor 22
CAS#: N/A
Chemical Formula: C21H23N5O2
Exact Mass: 377.19
Molecular Weight: 377.450
Elemental Analysis: C, 66.83; H, 6.14; N, 18.55; O, 8.48

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: ELOVL1 inhibitor 22; ELOVL1-inhibitor-22; ELOVL1inhibitor22; ELOVL1inhibitor 22; ELOVL1 inhibitor22

IUPAC/Chemical Name: (2R)-4-(6-(3-(1H-pyrazol-1-yl)cyclobutoxy)pyrimidin-4-yl)-2-phenylmorpholine

InChi Key: JXGFJBHPOCYADP-MNNMKWMVSA-N

InChi Code: InChI=1S/C21H23N5O2/c1-2-5-16(6-3-1)19-14-25(9-10-27-19)20-13-21(23-15-22-20)28-18-11-17(12-18)26-8-4-7-24-26/h1-8,13,15,17-19H,9-12,14H2/t17?,18-,19-/m0/s1

SMILES Code: C1([C@H]2OCCN(C3=NC=NC(O[C@@H]4CC(N5N=CC=C5)C4)=C3)C2)=CC=CC=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 377.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. Boyd MJ, Collier PN, Clark MP, Deng H, Kesavan S, Ronkin SM, Waal N, Wang J, Cao J, Li P, Come J, Davies I, Duffy JP, Cochran JE, Court JJ, Chandupatla K, Jackson KL, Maltais F, O'Dowd H, Boucher C, Considine T, Taylor WP, Gao H, Chakilam A, Engtrakul J, Crawford D, Doyle E, Phillips J, Kemper R, Swett R, Empfield J, Bunnage ME, Charifson PS, Magavi SS. Discovery of Novel, Orally Bioavailable Pyrimidine Ether-Based Inhibitors of ELOVL1. J Med Chem. 2021 Dec 23;64(24):17777-17794. doi: 10.1021/acs.jmedchem.1c00948. Epub 2021 Dec 6. PMID: 34871500.