WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H112027
CAS#: 2313525-90-3
Description: LEI-110 is an inhibitor of adipose phospholipase A2 (AdPLA2; IC50 = 100 nM). It also inhibits HRas-like suppressor 2 (HRASL2), retinoid acid receptor responder protein 3 (RARRES3), and calcium-independent N-acyltransferase (iNAT; IC50s = 158, 158, and 25 nM, respectively). LEI-110 (10 µM) decreases arachidonic acid levels in U2OS cells expressing human AdPLA2 and prevents oleic acid-induced increases in lipid droplet formation in HepG2 cells.
Hodoodo Cat#: H112027
Name: LEI-110
CAS#: 2313525-90-3
Chemical Formula: C25H23F3N2O3
Exact Mass: 456.17
Molecular Weight: 456.470
Elemental Analysis: C, 65.78; H, 5.08; F, 12.49; N, 6.14; O, 10.51
Synonym: LEI-110; LEI110; LEI 110
IUPAC/Chemical Name: 2-oxo-5-phenyl-N-(4-((5-(trifluoromethyl)pyridin-2-yl)oxy)phenethyl)pentanamide
InChi Key: DZHZISUSQMPBJQ-UHFFFAOYSA-N
InChi Code: InChI=1S/C25H23F3N2O3/c26-25(27,28)20-11-14-23(30-17-20)33-21-12-9-19(10-13-21)15-16-29-24(32)22(31)8-4-7-18-5-2-1-3-6-18/h1-3,5-6,9-14,17H,4,7-8,15-16H2,(H,29,32)
SMILES Code: O=C(NCCC1=CC=C(OC2=CC=C(C=N2)C(F)(F)F)C=C1)C(CCCC3=CC=CC=C3)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 456.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Zhou J, Mock ED, Martella A, Kantae V, Di X, Burggraaff L, Baggelaar MP, Al- Ayed K, Bakker A, Florea BI, Grimm SH, den Dulk H, Li CT, Mulder L, Overkleeft HS, Hankemeier T, van Westen GJP, van der Stelt M. Activity-Based Protein Profiling Identifies α-Ketoamides as Inhibitors for Phospholipase A2 Group XVI. ACS Chem Biol. 2019 Feb 15;14(2):164-169. doi: 10.1021/acschembio.8b00969. Epub 2019 Jan 18. PMID: 30620559; PMCID: PMC6379856.