WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H112032
CAS#: 52438-21-8
Description: 1-Cinnamoylpyrrolidine is an amide that has been found in P. taiwanense and has antiplatelet and DNA-cleaving activities. It inhibits arachidonic acid- or collagen-induced aggregation of isolated washed rabbit platelets (IC50s = 30.5 and 37.3 µM, respectively). 1-Cinnamoylpyrrolidine (250 µM) cleaves DNA in a cell-free DNA strand scission assay in the presence, but not absence, of copper ions.
Hodoodo Cat#: H112032
Name: 1-Cinnamoylpyrrolidine
CAS#: 52438-21-8
Chemical Formula: C13H15NO
Exact Mass: 201.12
Molecular Weight: 201.270
Elemental Analysis: C, 77.58; H, 7.51; N, 6.96; O, 7.95
Synonym: 1-Cinnamoylpyrrolidine; 1Cinnamoylpyrrolidine; 1 Cinnamoylpyrrolidine
IUPAC/Chemical Name: (E)-3-phenyl-1-(pyrrolidin-1-yl)prop-2-en-1-one
InChi Key: JSIGICUAXLIURX-CMDGGOBGSA-N
InChi Code: InChI=1S/C13H15NO/c15-13(14-10-4-5-11-14)9-8-12-6-2-1-3-7-12/h1-3,6-9H,4-5,10-11H2/b9-8+
SMILES Code: O=C(/C=C/C1=CC=CC=C1)N2CCCC2
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
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The following data is based on the product molecular weight 201.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Chen IS, Chen YC, Liao CH. Amides with anti-platelet aggregation activity from Piper taiwanense. Fitoterapia. 2007 Sep;78(6):414-9. doi: 10.1016/j.fitote.2007.04.009. Epub 2007 May 24. PMID: 17590283.
2: Ma J, Jones SH, Hecht SM. Phenolic acid amides: a new type of DNA strand scission agent from Piper caninum. Bioorg Med Chem. 2004 Jul 15;12(14):3885-9. doi: 10.1016/j.bmc.2004.05.007. PMID: 15210155.
