WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H208188
CAS#: 2765251-12-3
Description: ZLWH-23 displayed efficient reduction against tau hyperphosphorylation on Ser-396 site in Tau (P301L) 293T cell model. Collectively, harmine-based derivatives could be considered as possible drug leads for the development of AD therapies.
Hodoodo Cat#: H208188
Name: ZLWH-23
CAS#: 2765251-12-3
Chemical Formula: C30H32FN5O2
Exact Mass: 513.25
Molecular Weight: 513.620
Elemental Analysis: C, 70.16; H, 6.28; F, 3.70; N, 13.64; O, 6.23
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Synonym: ZLWH23, ZLWH 23, ZL-WH23
IUPAC/Chemical Name: 1-(Cyclopropanecarboxamido)-N-(2-(1-(2-fluorobenzyl)piperidin-4-yl)ethyl)-9H-pyrido[3,4-b]indole-7-carboxamide
InChi Key: AMLAWNFGPZNOOW-UHFFFAOYSA-N
InChi Code: InChI=1S/C30H32FN5O2/c31-25-4-2-1-3-22(25)18-36-15-11-19(12-16-36)9-13-33-29(37)21-7-8-23-24-10-14-32-28(27(24)34-26(23)17-21)35-30(38)20-5-6-20/h1-4,7-8,10,14,17,19-20,34H,5-6,9,11-13,15-16,18H2,(H,33,37)(H,32,35,38)
SMILES Code: O=C(C1=CC2=C(C=C1)C3=C(C(NC(C4CC4)=O)=NC=C3)N2)NCCC5CCN(CC6=CC=CC=C6F)CC5
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 513.62 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
Liu W, Liu X, Liu W, Gao Y, Wu L, Huang Y, Chen H, Li D, Zhou L, Wang N, Xu Z, Jiang X, Zhao Q. Discovery of novel β-carboline derivatives as selective AChE inhibitors with GSK-3β inhibitory property for the treatment of Alzheimer's disease. Eur J Med Chem. 2022 Feb 5;229:114095. doi: 10.1016/j.ejmech.2021.114095. Epub 2021 Dec 30. PMID: 34995924.