WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H208218
CAS#: 364762-78-7
Description: Osteoblast differentiation inducer is an inducer of the differentiation of undifferentiated cells
Hodoodo Cat#: H208218
Name: Osteoblast differentiation inducer
CAS#: 364762-78-7
Chemical Formula: C29H25N3O4S
Exact Mass: 511.16
Molecular Weight: 511.600
Elemental Analysis: Chemical Formula: C29H25N3O4S Exact Mass: 511.1566 Molecular Weight: 511.5960 Elemental Analysis: C, 68.08; H, 4.93; N, 8.21; O, 12.51; S, 6.27
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
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Note: Price will be listed if it is available in the future.
Synonym: Osteoblastdifferentiationinducer, Osteoblast-differentiation-inducer
IUPAC/Chemical Name: Ethyl 1-methyl-8-(4-(quinolin-2-ylmethoxy)phenoxy)-4,5-dihydro-1H-thieno[3,4-g]indazole-6-carboxylate
InChi Key: IPMNTZSIDFYQQM-UHFFFAOYSA-N
InChi Code: InChI=1S/C29H25N3O4S/c1-3-34-28(33)27-23-15-9-19-16-30-32(2)26(19)25(23)29(37-27)36-22-13-11-21(12-14-22)35-17-20-10-8-18-6-4-5-7-24(18)31-20/h4-8,10-14,16H,3,9,15,17H2,1-2H3
SMILES Code: O=C(C1=C2CCC3=C(N(C)N=C3)C2=C(OC4=CC=C(OCC5=NC6=CC=CC=C6C=C5)C=C4)S1)OCC
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 511.60 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
This message contains search results from the National Center for Biotechnology Information (NCBI) at the U.S. National Library of Medicine (NLM). Do not reply directly to this message
Sent On: Thu Aug 04 12:50:33 2022
Search: Osteoblast differentiation inducer
10 selected items
PubMed Results
Items 1-10 of 10 (Display the 10 citations in PubMed)
1: Komori T. Runx2, an inducer of osteoblast and chondrocyte differentiation. Histochem Cell Biol. 2018 Apr;149(4):313-323. doi: 10.1007/s00418-018-1640-6. Epub 2018 Jan 22. PMID: 29356961.
2: Li W, Zhang S, Liu J, Liu Y, Liang Q. Vitamin K2 stimulates MC3T3‑E1 osteoblast differentiation and mineralization through autophagy induction. Mol Med Rep. 2019 May;19(5):3676-3684. doi: 10.3892/mmr.2019.10040. Epub 2019 Mar 15. PMID: 30896842; PMCID: PMC6472126.
3: Ma J, Wang Z, Zhao J, Miao W, Ye T, Chen A. Resveratrol Attenuates Lipopolysaccharides (LPS)-Induced Inhibition of Osteoblast Differentiation in MC3T3-E1 Cells. Med Sci Monit. 2018 Apr 6;24:2045-2052. doi: 10.12659/msm.905703. PMID: 29624568; PMCID: PMC5903312.
4: Komori T. Regulation of Proliferation, Differentiation and Functions of Osteoblasts by Runx2. Int J Mol Sci. 2019 Apr 4;20(7):1694. doi: 10.3390/ijms20071694. PMID: 30987410; PMCID: PMC6480215.
5: Sekiguchi Y, Mano H, Nakatani S, Shimizu J, Kataoka A, Ogura K, Kimira Y, Ebata M, Wada M. Mangiferin positively regulates osteoblast differentiation and suppresses osteoclast differentiation. Mol Med Rep. 2017 Aug;16(2):1328-1332. doi: 10.3892/mmr.2017.6752. Epub 2017 Jun 12. PMID: 28627701; PMCID: PMC5562065.
6: Yin N, Zhu L, Ding L, Yuan J, Du L, Pan M, Xue F, Xiao H. MiR-135-5p promotes osteoblast differentiation by targeting HIF1AN in MC3T3-E1 cells. Cell Mol Biol Lett. 2019 Aug 8;24:51. doi: 10.1186/s11658-019-0177-6. PMID: 31410089; PMCID: PMC6686269.
7: Kim YH, Jang WG, Oh SH, Kim JW, Lee MN, Song JH, Yang JW, Zang Y, Koh JT. Fenofibrate induces PPARα and BMP2 expression to stimulate osteoblast differentiation. Biochem Biophys Res Commun. 2019 Dec 3;520(2):459-465. doi: 10.1016/j.bbrc.2019.10.048. Epub 2019 Oct 10. PMID: 31607484.
8: Vidoni C, Ferraresi A, Secomandi E, Vallino L, Gardin C, Zavan B, Mortellaro C, Isidoro C. Autophagy drives osteogenic differentiation of human gingival mesenchymal stem cells. Cell Commun Signal. 2019 Aug 19;17(1):98. doi: 10.1186/s12964-019-0414-7. PMID: 31426798; PMCID: PMC6701103.
9: Zeng HB, Dong LQ, Xu C, Zhao XH, Wu LG. Artesunate promotes osteoblast differentiation through miR-34a/DKK1 axis. Acta Histochem. 2020 Oct;122(7):151601. doi: 10.1016/j.acthis.2020.151601. Epub 2020 Aug 17. PMID: 33066846.
10: Narayanan A, Srinaath N, Rohini M, Selvamurugan N. Regulation of Runx2 by MicroRNAs in osteoblast differentiation. Life Sci. 2019 Sep 1;232:116676. doi: 10.1016/j.lfs.2019.116676. Epub 2019 Jul 21. PMID: 31340165.
