WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H112163
CAS#: 53155-25-2
Description: Euscaphic acid is a triterpene that inhibits the proliferation of CNE-1 and C666-1 nasopharyngeal carcinoma cells.
Hodoodo Cat#: H112163
Name: Euscaphic Acid
CAS#: 53155-25-2
Chemical Formula: C30H48O5
Exact Mass: 488.35
Molecular Weight: 488.710
Elemental Analysis: C, 73.73; H, 9.90; O, 16.37
Synonym: Euscaphic Acid
IUPAC/Chemical Name: (1R,2R,4aS,6aS,6bR,8aR,10S,11R,12aR,12bR,14bS)-1,10,11-trihydroxy-1,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-octadecahydropicene-4a(2H)-carboxylic acid
InChi Key: OXVUXGFZHDKYLS-QUFHAEKXSA-N
InChi Code: InChI=1S/C30H48O5/c1-17-10-13-30(24(33)34)15-14-27(5)18(22(30)29(17,7)35)8-9-21-26(4)16-19(31)23(32)25(2,3)20(26)11-12-28(21,27)6/h8,17,19-23,31-32,35H,9-16H2,1-7H3,(H,33,34)/t17-,19-,20+,21-,22-,23-,26+,27-,28-,29-,30+/m1/s1
SMILES Code: C[C@@H]1CC[C@]2(C(O)=O)CC[C@@]3(C)[C@]4(C)CC[C@@]5([H])C(C)(C)[C@H](O)[C@H](O)C[C@]5(C)[C@@]4([H])CC=C3[C@]2([H])[C@]1(C)O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 488.71 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Shi C, Li Z, Wu Y, Li X, Li Y, Wei J, Li J, Zhang Y, Li L. Euscaphic acid and Tormentic acid protect vascular endothelial cells against hypoxia-induced apoptosis via PI3K/AKT or ERK 1/2 signaling pathway. Life Sci. 2020 Jul 1;252:117666. doi: 10.1016/j.lfs.2020.117666. Epub 2020 Apr 13. PMID: 32298737.
2: Dai W, Dong P, Liu J, Gao Y, Hu Y, Lin H, Song Y, Mei Q. Euscaphic acid inhibits proliferation and promotes apoptosis of nasopharyngeal carcinoma cells by silencing the PI3K/AKT/mTOR signaling pathway. Am J Transl Res. 2019 Apr 15;11(4):2090-2098. PMID: 31105820; PMCID: PMC6511751.
3: Li JJ, Li Y, Bai M, Tan JF, Wang Q, Yang J. Simultaneous determination of corosolic acid and euscaphic acid in the plasma of normal and diabetic rat after oral administration of extract of Potentilla discolor Bunge by high-performance liquid chromatography/electrospray ionization mass spectrometry. Biomed Chromatogr. 2014 May;28(5):717-24. doi: 10.1002/bmc.3098. Epub 2013 Dec 6. PMID: 24311372.
4: Jeong NH, Lee S, Choi YA, Song KS, Kim SH. Inhibitory Effects of Euscaphic Acid in the Atopic Dermatitis Model by Reducing Skin Inflammation and Intense Pruritus. Inflammation. 2022 Aug;45(4):1680-1691. doi: 10.1007/s10753-022-01652-x. Epub 2022 Mar 7. PMID: 35257273.
5: Kim IT, Ryu S, Shin JS, Choi JH, Park HJ, Lee KT. Euscaphic acid isolated from roots of Rosa rugosa inhibits LPS-induced inflammatory responses via TLR4-mediated NF-κB inactivation in RAW 264.7 macrophages. J Cell Biochem. 2012 Jun;113(6):1936-46. doi: 10.1002/jcb.24062. PMID: 22234926.
6: Chen J, Li WL, Wu JL, Ren BR, Zhang HQ. Euscaphic acid, a new hypoglycemic natural product from Folium Eriobotryae. Pharmazie. 2008 Oct;63(10):765-7. PMID: 18972842.
