WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H208343
CAS#: unknown
Description: RTI-7470-44 is a potent hTAAR1 antagonist. RTI-7470-44 displayed good blood-brain barrier permeability, moderate metabolic stability, and a favorable preliminary off-target profile.
Hodoodo Cat#: H208343
Name: RTI-7470-44
CAS#: unknown
Chemical Formula: C19H11ClF3N5OS
Exact Mass: 449.03
Molecular Weight: 449.840
Elemental Analysis: C, 50.73; H, 2.46; Cl, 7.88; F, 12.67; N, 15.57; O, 3.56; S, 7.13
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Synonym: RTI747044, RTI7470-44
IUPAC/Chemical Name: 2-((6-(4-Chlorophenyl)-3-cyano-4-(trifluoromethyl)pyridin-2-yl)thio)-N-(pyrimidin-2-yl)acetamide
InChi Key: WHNQNKYKDSLDKM-UHFFFAOYSA-N
InChi Code: InChI=1S/C19H11ClF3N5OS/c20-12-4-2-11(3-5-12)15-8-14(19(21,22)23)13(9-24)17(27-15)30-10-16(29)28-18-25-6-1-7-26-18/h1-8H,10H2,(H,25,26,28,29)
SMILES Code: O=C(NC1=NC=CC=N1)CSC2=NC(C3=CC=C(Cl)C=C3)=CC(C(F)(F)F)=C2C#N
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 449.84 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
Decker AM, Brackeen MF, Mohammadkhani A, Kormos CM, Hesk D, Borgland SL, Blough BE. Identification of a Potent Human Trace Amine-Associated Receptor 1 Antagonist. ACS Chem Neurosci. 2022 Apr 6;13(7):1082-1095. doi: 10.1021/acschemneuro.2c00086. Epub 2022 Mar 24. PMID: 35325532.