WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H208364
CAS#: 42951-68-8
Description: EB1 is a binding partner of the tumor suppressor adenomatous polyposis coli (APC). APC binding to EB1 promotes EB1 association with microtubule ends and microtubule stabilization
Hodoodo Cat#: H208364
Name: EB1
CAS#: 42951-68-8
Chemical Formula: C18H14N4
Exact Mass: 286.12
Molecular Weight: 286.340
Elemental Analysis: C, 75.50; H, 4.93; N, 19.57
Synonym: E-B1, E-B-1
IUPAC/Chemical Name: 4,6-Diphenyl-2H-pyrazolo[3,4-b]pyridin-3-amine
InChi Key: NGNHXYCLUMQSKR-UHFFFAOYSA-N
InChi Code: InChI=1S/C18H14N4/c19-17-16-14(12-7-3-1-4-8-12)11-15(20-18(16)22-21-17)13-9-5-2-6-10-13/h1-11H,(H3,19,20,21,22)
SMILES Code: NC1=C(C(C2=CC=CC=C2)=CC(C3=CC=CC=C3)=N4)C4=NN1
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 286.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
Juanes MA, Fees CP, Hoeprich GJ, Jaiswal R, Goode BL. EB1 Directly Regulates APC-Mediated Actin Nucleation. Curr Biol. 2020 Dec 7;30(23):4763-4772.e8. doi: 10.1016/j.cub.2020.08.094. Epub 2020 Oct 1. PMID: 33007249; PMCID: PMC7726095.