WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H208379
CAS#: unknown
Description: C5-RIBOTAC is a RIBOTAC degrader, targeting the SARS-CoV-2 RNA genome
Hodoodo Cat#: H208379
Name: C5-RIBOTAC
CAS#: unknown
Chemical Formula: C44H46N6O9S
Exact Mass: 834.30
Molecular Weight: 834.950
Elemental Analysis: C, 63.30; H, 5.55; N, 10.07; O, 17.25; S, 3.84
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Synonym: C5RIBOTAC, C5RIBO-TAC
IUPAC/Chemical Name: Ethyl (Z)-5-(3-hydroxy-4-((1-(3-((4-(methylamino)quinazolin-2-yl)amino)phenyl)-1-oxo-5,8,11-trioxa-2-azatridecan-13-yl)oxy)benzylidene)-4-oxo-2-(phenylamino)-4,5-dihydrothiophene-3-carboxylate
InChi Key: QNIXDZUDPGMHGJ-QOSQFQCFSA-N
InChi Code: InChI=1S/C44H46N6O9S/c1-3-58-43(54)38-39(52)37(60-42(38)47-31-11-5-4-6-12-31)27-29-16-17-36(35(51)26-29)59-25-24-57-23-22-56-21-20-55-19-18-46-41(53)30-10-9-13-32(28-30)48-44-49-34-15-8-7-14-33(34)40(45-2)50-44/h4-17,26-28,47,51H,3,18-25H2,1-2H3,(H,46,53)(H2,45,48,49,50)/b37-27-
SMILES Code: O=C(C(C/1=O)=C(NC2=CC=CC=C2)SC1=C/C3=CC=C(OCCOCCOCCOCCNC(C4=CC=CC(NC5=NC(NC)=C6C=CC=CC6=N5)=C4)=O)C(O)=C3)OCC
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 834.95 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
Haniff HS, Tong Y, Liu X, Chen JL, Suresh BM, Andrews RJ, Peterson JM, O'Leary CA, Benhamou RI, Moss WN, Disney MD. Targeting the SARS-CoV-2 RNA Genome with Small Molecule Binders and Ribonuclease Targeting Chimera (RIBOTAC) Degraders. ACS Cent Sci. 2020 Oct 28;6(10):1713-1721. doi: 10.1021/acscentsci.0c00984. Epub 2020 Sep 30. PMID: 33140033; PMCID: PMC7553039.