Aderbasib
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Hodoodo CAT#: H200080

CAS#: 791828-58-5

Description: Aderbasib, also known as INCB007839, is a sheddase inhibitor, is also an orally bioavailable inhibitor of the ADAM (A Disintegrin And Metalloprotease) family of multifunctional membrane-bound proteins with potential antineoplastic activity. Aderbasib represses the metalloproteinase "sheddase" activities of ADAM10 and ADAM17, which may result in the inhibition of tumor cell proliferation. The metalloproteinase domains of ADAMs cleave cell surface proteins at extracellular sites proximal to the cell membrane, releasing or "shedding" soluble protein etcodomains from the cell surface; the disintegrin domains of these multifunctional proteins interact with various components of the extracellular matrix (ECM).


Chemical Structure

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Aderbasib
CAS# 791828-58-5

Theoretical Analysis

Hodoodo Cat#: H200080
Name: Aderbasib
CAS#: 791828-58-5
Chemical Formula: C21H28N4O5
Exact Mass: 416.21
Molecular Weight: 416.471
Elemental Analysis: C, 60.56; H, 6.78; N, 13.45; O, 19.21

Price and Availability

Size Price Availability Quantity
1mg USD 250 Ready to ship
2mg USD 400 Ready to ship
5mg USD 850 Ready to ship
10mg USD 1350 Ready to ship
25mg USD 2850 Ready to ship
50mg USD 3950 Ready to ship
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Synonym: INCB7839; INCB 7839; INCB-7839; INCB007839; INCB 007839; INCB-007839; Aderbasib.

IUPAC/Chemical Name: (6S,7S)-7-[(Hydroxyamino)carbonyl]-6-[(4-phenyl-1-piperazinyl)carbonyl]-5-azaspiro[2.5]octane-5-carboxylic acid methyl ester

InChi Key: DJXMSZSZEIKLQZ-IRXDYDNUSA-N

InChi Code: InChI=1S/C21H28N4O5/c1-30-20(28)25-14-21(7-8-21)13-16(18(26)22-29)17(25)19(27)24-11-9-23(10-12-24)15-5-3-2-4-6-15/h2-6,16-17,29H,7-14H2,1H3,(H,22,26)/t16-,17-/m0/s1

SMILES Code: O=C(N([C@H](C(N1CCN(C2=CC=CC=C2)CC1)=O)[C@@H](C(NO)=O)C3)CC43CC4)OC

Appearance: Solid powder

Purity: >95% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >5 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:  Aderbasib was being developed by Incyte as a potential adjunctive treatment for metastatic breast cancer. Development was halted in 2011 after positive findings from Phase II trials were contradicted by further research. (http://en.wikipedia.org/wiki/Aderbasib).    

Biological target: Aderbasib (INCB007839) is a potent, orally active and target specific low nanomolar hydroxamate-based inhibitor of ADAM10 and ADAM17 that exhibits robust antineoplastic activity.
In vitro activity: TBD
In vivo activity: HER-2/neu+ BT474-SC1 human breast cancer xenografts were established. INCB7839 was administered at a dose capable of achieving steady-state levels of 500 nmol/L to 1 μmol/L in plasma. This concentration was previously determined to be above the IC50 for HER-2/neu and EGFR ligand shedding. Treatment with the INCB7839 sheddase inhibitor resulted in a decrease in mean tumor volume compared with animals treated with the vehicle. Reference: Cancer Res. 2008 Sep 1;68(17):7083-9. https://cancerres.aacrjournals.org/content/68/17/7083.long

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 100.0 240.11

Preparing Stock Solutions

The following data is based on the product molecular weight 416.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: 1. Witters L, Scherle P, Friedman S, Fridman J, Caulder E, Newton R, Lipton A. Synergistic inhibition with a dual epidermal growth factor receptor/HER-2/neu tyrosine kinase inhibitor and a disintegrin and metalloprotease inhibitor. Cancer Res. 2008 Sep 1;68(17):7083-9. doi: 10.1158/0008-5472.CAN-08-0739. PMID: 18757423.
In vitro protocol: TBD
In vivo protocol: 1. Witters L, Scherle P, Friedman S, Fridman J, Caulder E, Newton R, Lipton A. Synergistic inhibition with a dual epidermal growth factor receptor/HER-2/neu tyrosine kinase inhibitor and a disintegrin and metalloprotease inhibitor. Cancer Res. 2008 Sep 1;68(17):7083-9. doi: 10.1158/0008-5472.CAN-08-0739. PMID: 18757423.

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