WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H205831
CAS#: 467421-06-3
Description: CC-1088 is an analog of thalidomide with potential antineoplastic activity that belongs to the functional class of agents called selective cytokine inhibitory drugs (SelCIDs). SelCIDs inhibit phosphodiesterase-4 (PDE 4), an enzyme involved in tumor necrosis factor alpha (TNF alpha) production. CC-1088 inhibits production of the cytokines vascular endothelial growth factor (VEGF) (a pro-angiogenic factor) and interleukin-6 (IL-6).
Hodoodo Cat#: H205831
Name: CC-1088
CAS#: 467421-06-3
Chemical Formula: C17H14N2O3
Exact Mass: 294.10
Molecular Weight: 294.310
Elemental Analysis: C, 69.38; H, 4.79; N, 9.52; O, 16.31
Synonym: CC1088; CC 1088; CC-1088.
IUPAC/Chemical Name: 3-(1,3-dioxoisoindolin-2-yl)-3-phenylpropanamide
InChi Key: ZJZWDDCSXLSDJG-UHFFFAOYSA-N
InChi Code: InChI=1S/C17H14N2O3/c18-15(20)10-14(11-6-2-1-3-7-11)19-16(21)12-8-4-5-9-13(12)17(19)22/h1-9,14H,10H2,(H2,18,20)
SMILES Code: O=C(C1=CC=CC=C12)N(C(C3=CC=CC=C3)CC(N)=O)C2=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >5 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 294.31 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Dredge K. CC-1088 Celgene. Curr Opin Investig Drugs. 2005 May;6(5):513-7.
Review. PubMed PMID: 15912966.
2: Molostvov G, Morris A, Rose P, Basu S, Muller G. The effects of selective
cytokine inhibitory drugs (CC-10004 and CC-1088) on VEGF and IL-6 expression and
apoptosis in myeloma and endothelial cell co-cultures. Br J Haematol. 2004
Feb;124(3):366-75. PubMed PMID: 14717786.