WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H201951
CAS#: NONE
Description: MPC-2130 is a broad-acting, apoptosis-inducing, small molecule with potential antineoplastic activity. Although the exact mechanism of action has yet to be fully elucidated, apoptosis inducer MPC-2130 exhibits proapoptotic activities in tumor cells, including membrane phosphatidylserine externalization, release of cytochrome C from mitochondria, caspase activation, cell condensation, and DNA fragmentation. In addition, because this agent is not a substrate for several types of multidrug resistance (MDR) ABC superfamily transporters, such as P-glycoprotein 1 (MDR-1), multidrug resistance-associated protein 1 (MRP1), and breast cancer resistance protein 1 (BCRP1/ABCG2), it may be useful in treating MDR tumors that express these particular MDR efflux pumps. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus).
Hodoodo Cat#: H201951
Name: MPC-2130
CAS#: NONE
Chemical Formula:
Exact Mass: 0.00
Molecular Weight: 0.000
Elemental Analysis:
Synonym: MPC2130; MPC-2130; MPC 2130.
IUPAC/Chemical Name: NONE
InChi Key:
InChi Code:
SMILES Code:
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not soluble in water.
Shelf Life: >5 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info: MPC-2130 was discovered at Myriad Pharmaceuticals, Inc. as a result of an extensive medicinal chemistry effort. The original lead compound, from which MPC-2130 was derived, was discovered in a yeast-based high throughput screen. Tumor cells treated with MPC-2130 display multiple indicators of apoptotic cell death, that include phosphatidylserine flipping to the outer cell membrane, release of cytochrome C from the mitochondria, caspase activation, cell condensation and DNA fragmentation. Research results suggest that MPC-2130 may be an effective therapy against multiple tumor types in humans. see Christopher Pleiman, Kimberly Mauck, Lynn Demie, Orvelin Roman, Lori Fotheringham, Daniel Von Hoff, Adrian Hobden, Robert Carlson and Gary Mather; Antitumor activity of MPC-2130 in human ovarian and prostate tumor xenografts in athymic nude mice; [Proc Amer Assoc Cancer Res, Volume 46, 2005; http://www.aacrmeetingabstracts.org/cgi/content/abstract/2005/1/151-c. MPC-2130 was discovered at Myriad Pharmaceuticals, Inc. as a result of an extensive medicinal chemistry effort. The original lead compound, from which MPC-2130 was derived, was discovered in a yeast-based high throughput screen. Tumor cells treated with MPC-2130 display multiple indicators of apoptotic cell death, that include phosphatidylserine flipping to the outer cell membrane, release of cytochrome C from the mitochondria, caspase activation, cell condensation and DNA fragmentation. Research results suggest that MPC-2130 may be an effective therapy against multiple tumor types in humans. see Christopher Pleiman, Kimberly Mauck, Lynn Demie, Orvelin Roman, Lori Fotheringham, Daniel Von Hoff, Adrian Hobden, Robert Carlson and Gary Mather; Antitumor activity of MPC-2130 in human ovarian and prostate tumor xenografts in athymic nude mice; [Proc Amer Assoc Cancer Res, Volume 46, 2005; http://www.aacrmeetingabstracts.org/cgi/content/abstract/2005/1/151-c.
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The following data is based on the product molecular weight 0.00 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
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