WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: 125732
CAS#: N/A
Description: YSR734 is a covalent HDAC inhibitor with cellular activity in acute myeloid leukemia and Duchenne muscular dystrophy. YSR734 showed nM potency against HDAC1−3, sub-μM activity in MV4−11 cells, and limited cytotoxicity in MRC-9 fibroblasts. In C2C12 myoblasts, YSR734 activated muscle-specific biomarkers myogenin/Cav3, causing potent differentiation into myotubes (applications in Duchenne Muscular Dystrophy).
Hodoodo Cat#: 125732
Name: YSR734
CAS#: N/A
Chemical Formula: C26H23F5N4O5S
Exact Mass: 598.13
Molecular Weight: 598.550
Elemental Analysis: C, 52.17; H, 3.87; F, 15.87; N, 9.36; O, 13.36; S, 5.36
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.
Synonym: YSR734; YSR-734; YSR 734
IUPAC/Chemical Name: 1-((perfluorophenyl)sulfonyl)piperidin-4-yl (4-((2-aminophenyl)carbamoyl)benzyl)carbamate
InChi Key: JGJZNWDPKNHILY-UHFFFAOYSA-N
InChi Code: InChI=1S/C26H23F5N4O5S/c27-19-20(28)22(30)24(23(31)21(19)29)41(38,39)35-11-9-16(10-12-35)40-26(37)33-13-14-5-7-15(8-6-14)25(36)34-18-4-2-1-3-17(18)32/h1-8,16H,9-13,32H2,(H,33,37)(H,34,36)
SMILES Code: O=C(OC1CCN(S(C2=C(F)C(F)=C(F)C(F)=C2F)(=O)=O)CC1)NCC3=CC=C(C(NC4=CC=CC=C4N)=O)C=C3
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 598.55 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
Raouf YS, Sedighi A, Geletu M, Frere GA, Allan RG, Nawar N, de Araujo ED, Gunning PT. Discovery of YSR734: A Covalent HDAC Inhibitor with Cellular Activity in Acute Myeloid Leukemia and Duchenne Muscular Dystrophy. J Med Chem. 2023 Dec 7. doi: 10.1021/acs.jmedchem.3c01236. Epub ahead of print. PMID: 38060537.