WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H202064
CAS#: 122933-59-9
Description: Oglufanide disodium is t he disodium salt of a synthetic form of a naturally-occurring dipeptide consisting of L-glutamic acid and L-tryptophan with potential antiangiogenic and potential immunomodulating activities. Oglufanide inhibits vascular endothelial growth factor (VEGF), which may inhibit angiogenesis. This agent has also been reported to stimulate the immune response to hepatitic C virus and intracellular bacterial infections. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Hodoodo Cat#: H202064
Name: Oglufanide disodium
CAS#: 122933-59-9
Chemical Formula: C16H17N3Na2O5
Exact Mass: 333.13
Molecular Weight: 377.300
Elemental Analysis: C, 57.65; H, 5.75; N, 12.61; O, 24.00
This product is not in stock, which may be available by custom synthesis.
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Synonym: NSC 334073; Oglufanide; Thymogen; Timogen; IM 862.
IUPAC/Chemical Name: (S)-4-amino-5-(((S)-1-carboxy-2-(1H-indol-3-yl)ethyl)amino)-5-oxopentanoic acid
InChi Key: LLEUXCDZPQOJMY-AAEUAGOBSA-N
InChi Code: InChI=1S/C16H19N3O5/c17-11(5-6-14(20)21)15(22)19-13(16(23)24)7-9-8-18-12-4-2-1-3-10(9)12/h1-4,8,11,13,18H,5-7,17H2,(H,19,22)(H,20,21)(H,23,24)/t11-,13-/m0/s1
SMILES Code: O=C(O)CC[C@H](N)C(N[C@H](C(O)=O)CC1=CNC2=C1C=CC=C2)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >5 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info: Oglufanide was originally developed to treat severe infectious disease in Russia (where it is a registered pharmaceutical), and was extensively studied in cancer clinical trials in the United States before being acquired by the privately-owned Brisbane biotech company Implicit Bioscience Pty Ltd in 2005. Oglufanide regulates the body's innate immune response to defeat invading germs and cancer cells. The drug is also under development by Implicit for severe respiratory diseases such as influenza (including pandemic disease) and ovarian cancer. Oglufanide has US Investigative New Drug status and Orphan Drug designation for cancer. see Company's news published in 2006.
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The following data is based on the product molecular weight 377.30 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
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1. National Center for Biotechnology Information. PubChem Compound Database; CID=158780, https://pubchem.ncbi.nlm.nih.gov/compound/158780 (accessed July 8, 2015).
