WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H406405
CAS#: 669764-17-4
Description: SU11606 is a potent c-MET inhibitor with potential anticancer activity.
Hodoodo Cat#: H406405
Name: SU11606
CAS#: 669764-17-4
Chemical Formula: C29H33ClN4O4S
Exact Mass: 568.19
Molecular Weight: 569.115
Elemental Analysis: C, 61.20; H, 5.84; Cl, 6.23; N, 9.84; O, 11.25; S, 5.63
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Synonym: SU11606; SU 11606; SU11606.
IUPAC/Chemical Name: (Z)-N-(3-chlorophenyl)-3-((3,5-dimethyl-4-(3-morpholinopropyl)-1H-pyrrol-2-yl)methylene)-N-methyl-2-oxoindoline-5-sulfonamide
InChi Key: JXOCDHNKTVLZLD-ITYLOYPMSA-N
InChi Code: InChI=1S/C29H33ClN4O4S/c1-19-24(8-5-11-34-12-14-38-15-13-34)20(2)31-28(19)18-26-25-17-23(9-10-27(25)32-29(26)35)39(36,37)33(3)22-7-4-6-21(30)16-22/h4,6-7,9-10,16-18,31H,5,8,11-15H2,1-3H3,(H,32,35)/b26-18-
SMILES Code: O=S(C1=CC2=C(NC(/C2=C\C3=C(C)C(CCCN4CCOCC4)=C(C)N3)=O)C=C1)(N(C5=CC=CC(Cl)=C5)C)=O
Appearance: yellow solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 569.11 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1. Golub, Todd; Straussman, Ravid. Methods of treating cancer using a chemotherapeutic agent with an agent that blocks the activity of hepatocyte growth factor or its cognate receptor c-MET. From PCT Int. Appl. (2012), WO 2012178038 A1 20121227.
2. Smith, David; Hussain, Maha. Dual inhibitors of Met and VEGF for the treatment of castration resistant prostate cancer and osteoblastic bone metastases. PCT Int. Appl. (2012), WO 2012044577 A1 20120405
3. Comoglio, Paolo Maria; Vigna, Elisa; Giordano, Silvia. Use of monoclonal antibody (AntiMET-R) directed against hepatocyte growth factor receptor (HGFR) for the treatment and diagnosis of tumors. PCT Int. Appl. (2007), WO 2007090807 A1 20070816.
4. Tang, Peng Cho; Liang, Congxin; Miller, Todd; Lipson, Kenneth E. Preparation of 5-sulfonamido-substituted indolinone compounds as protein kinase inhibitors. U.S. Pat. Appl. Publ. (2004), US 20040204407 A1 20041014
5. Wang, Xueyan; Le, Phuong; Liang, Congxin; Chan, Julie; Kiewlich, David; Miller, Todd; Harris, Dave; Sun, Li; Rice, Audie; Vasile, Stefan; et al. Potent and selective inhibitors of the Met [hepatocyte growth factor/scatter factor (HGF/SF) receptor] tyrosine kinase block HGF/SF-induced tumor cell growth and invasion. Molecular Cancer Therapeutics (2003), 2(11), 1085-1092.
