Rilapladib

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H319503

CAS#: 412950-08-4

Description: Rilapladib, aslo known as SB-659032 and GTPL7376, is a lipoprotein-associated phospholipase A2 inhibitor.

Chemical Structure

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Rilapladib
CAS# 412950-08-4
Instruction

Theoretical Analysis

Hodoodo Cat#: H319503
Name: Rilapladib
CAS#: 412950-08-4
Chemical Formula: C40H38F5N3O3S
Exact Mass: 735.26
Molecular Weight: 735.814
Elemental Analysis: C, 65.29; H, 5.21; F, 12.91; N, 5.71; O, 6.52; S, 4.36

Price and Availability

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Synonym: SB-659032; SB659032; SB 659032; GTPL7376; GTPL-7376; GTPL 7376; D05728; Rilapladib

IUPAC/Chemical Name: 2-[2-[(2,3-difluorophenyl)methylsulfanyl]-4-oxoquinolin-1-yl]-N-[1-(2-methoxyethyl)piperidin-4-yl]-N-[[4-[4-(trifluoromethyl)phenyl]phenyl]methyl]acetamide

InChi Key: NNBGCSGCRSCFEA-UHFFFAOYSA-N

InChi Code: InChI=1S/C40H38F5N3O3S/c1-51-22-21-46-19-17-32(18-20-46)47(24-27-9-11-28(12-10-27)29-13-15-31(16-14-29)40(43,44)45)37(50)25-48-35-8-3-2-6-33(35)36(49)23-38(48)52-26-30-5-4-7-34(41)39(30)42/h2-16,23,32H,17-22,24-26H2,1H3

SMILES Code: O=C(N(C1CCN(CCOC)CC1)CC2=CC=C(C3=CC=C(C(F)(F)F)C=C3)C=C2)CN4C(SCC5=CC=CC(F)=C5F)=CC(C6=C4C=CC=C6)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 735.81 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Shaddinger BC, Xu Y, Roger JH, Macphee CH, Handel M, Baidoo CA, Magee M,
Lepore JJ, Sprecher DL. Platelet aggregation unchanged by lipoprotein-associated
phospholipase A₂ inhibition: results from an in vitro study and two randomized
phase I trials. PLoS One. 2014 Jan 27;9(1):e83094. doi:
10.1371/journal.pone.0083094. eCollection 2014. PubMed PMID: 24475026; PubMed
Central PMCID: PMC3903475.


2: Tawakol A, Singh P, Rudd JH, Soffer J, Cai G, Vucic E, Brannan SP, Tarka EA,
Shaddinger BC, Sarov-Blat L, Matthews P, Subramanian S, Farkouh M, Fayad ZA.
Effect of treatment for 12 weeks with rilapladib, a lipoprotein-associated
phospholipase A2 inhibitor, on arterial inflammation as assessed with
18F-fluorodeoxyglucose-positron emission tomography imaging. J Am Coll Cardiol.
2014 Jan 7-14;63(1):86-8. doi: 10.1016/j.jacc.2013.07.050. Epub 2013 Aug 21.
PubMed PMID: 23973698.