WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H319571
CAS#: 1477482-19-1
Description: Erlosiban, also known as OBE001, is a novel, orally active nonpeptide oxytocin receptor antagonist under development for the treatment of preterm labor and improvement in embryo implantation and pregnancy rate in assisted reproductive technology (ART).
Hodoodo Cat#: H319571
Name: Erlosiban
CAS#: 1477482-19-1
Chemical Formula: C20H22N2O3
Exact Mass: 338.16
Molecular Weight: 338.410
Elemental Analysis: C, 70.99; H, 6.55; N, 8.28; O, 14.18
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.
Synonym: OBE-001; OBE001; OBE001; Erlosiban; Nolasiban
IUPAC/Chemical Name: [(2S,4Z)-2-(hydroxymethyl)-4-(methoxyimino)pyrrolidin-1-yl](2'-methyl[1,1'-biphenyl]-4-yl)methanone
InChi Key: OLUJSZLBWZWGJT-HGBKYHTQSA-N
InChi Code: InChI=1S/C20H22N2O3/c1-14-5-3-4-6-19(14)15-7-9-16(10-8-15)20(24)22-12-17(21-25-2)11-18(22)13-23/h3-10,18,23H,11-13H2,1-2H3/b21-17-/t18-/m0/s1
SMILES Code: O=C(N1[C@H](CO)C/C(C1)=N/OC)C2=CC=C(C3=CC=CC=C3C)C=C2
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 338.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Pohl O, Perks D, Rhodes J, Comotto L, Baldrick P, Chollet A. Effects of the
Oral Oxytocin Receptor Antagonist Tocolytic OBE001 on Reproduction in Rats.
Reprod Sci. 2015 Sep 23. pii: 1933719115607979. [Epub ahead of print] PubMed
PMID: 26399985.
2: Pohl O, Homery MC, Lemaux F, Patat A, Chollet A. Pharmacokinetic interactions
of OBE001 and betamethasone in healthy female volunteers. J Clin Pharm Ther. 2015
Jun;40(3):328-32. doi: 10.1111/jcpt.12258. Epub 2015 Feb 26. PubMed PMID:
25899007.