WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H206494
CAS#: 1637573-04-6 (Ralaniten acetate)
Description: Ralaniten acetate, also known as EPI-506, is a potent and selective NTD inhibitor (inhibitor of the androgen receptor (AR) N-terminal domain (NTD)). In vitro and in vivo studies have shown activity against full length AR and constitutively active AR splice variants, including AR-V7 (associated with resistance to abiraterone and enzalutamide). EPI-506 is expected to be effective in mCRPC driven by both canonical and aberrant AR signaling by targeting the NTD common to full length and splice variant AR. EPI-506 is the first agent with the potential to inhibit both canonical and variant-mediated AR signaling.
Hodoodo Cat#: H206494
Name: Ralaniten acetate
CAS#: 1637573-04-6 (Ralaniten acetate)
Chemical Formula: C27H33ClO8
Exact Mass: 520.19
Molecular Weight: 521.003
Elemental Analysis: C, 62.24; H, 6.38; Cl, 6.80; O, 24.57
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Related CAS #: 1203490-23-6 (Ralaniten) 1637573-04-6 (Ralaniten acetate),
Synonym: EPI-506; EPI 506; EPI506; Ralaniten acetate
IUPAC/Chemical Name: (S)-3-(4-(2-(4-((S)-2-acetoxy-3-chloropropoxy)phenyl)propan-2-yl)phenoxy)propane-1,2-diyl diacetate
InChi Key: HGHVYYKTOXUQNT-CLJLJLNGSA-N
InChi Code: InChI=1S/C27H33ClO8/c1-18(29)32-16-26(36-20(3)31)17-34-24-12-8-22(9-13-24)27(4,5)21-6-10-23(11-7-21)33-15-25(14-28)35-19(2)30/h6-13,25-26H,14-17H2,1-5H3/t25-,26-/m1/s1
SMILES Code: CC(C1=CC=C(OC[C@H](OC(C)=O)COC(C)=O)C=C1)(C2=CC=C(OC[C@H](OC(C)=O)CCl)C=C2)C
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 521.00 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Maughan BL, Antonarakis ES. Clinical Relevance of Androgen Receptor Splice
Variants in Castration-Resistant Prostate Cancer. Curr Treat Options Oncol. 2015
Dec;16(12):57. doi: 10.1007/s11864-015-0375-z. PubMed PMID: 26537882.
