WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H522542
CAS#: 1168138-37-1
Description: GSK1997132B is a potent, metabolically stable and centrally penetrant PPARγ partial agonist.
Hodoodo Cat#: H522542
Name: GSK1997132B
CAS#: 1168138-37-1
Chemical Formula: C24H22F2N4O
Exact Mass: 420.18
Molecular Weight: 420.460
Elemental Analysis: C, 68.56; H, 5.27; F, 9.04; N, 13.33; O, 3.81
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Synonym: GSK 1997132B; GSK-1997132B; GSK1997132B; GSK1997132; GSK-1997132; GSK 1997132.
IUPAC/Chemical Name: (R)-1-((3,5-difluoropyridin-2-yl)methyl)-2-methyl-N-(1-phenylpropyl)-1H-benzo[d]imidazole-5-carboxamide
InChi Key: VYCNCLBUJAXONJ-HXUWFJFHSA-N
InChi Code: InChI=1S/C24H22F2N4O/c1-3-20(16-7-5-4-6-8-16)29-24(31)17-9-10-23-21(11-17)28-15(2)30(23)14-22-19(26)12-18(25)13-27-22/h4-13,20H,3,14H2,1-2H3,(H,29,31)/t20-/m1/s1
SMILES Code: O=C(C1=CC=C2N(CC3=NC=C(F)C=C3F)C(C)=NC2=C1)N[C@@H](C4=CC=CC=C4)CC
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 420.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Sime M, Allan AC, Chapman P, Fieldhouse C, Giblin GM, Healy MP, Lambert MH,
Leesnitzer LM, Lewis A, Merrihew RV, Rutter RA, Sasse R, Shearer BG, Willson TM,
Xu RX, Virley DJ. Discovery of GSK1997132B a novel centrally penetrant
benzimidazole PPARγ partial agonist. Bioorg Med Chem Lett. 2011 Sep
15;21(18):5568-72. doi: 10.1016/j.bmcl.2011.06.088. Epub 2011 Jun 29. Erratum in:
Bioorg Med Chem Lett. 2013 Feb 15;23(4):1143. Wilson, Timothy M [corrected to
Willson, Timothy M]. PubMed PMID: 21798739.