WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H522544
CAS#: 175026-96-7
Description: NQDI-1 is an inhibitor of ASK1, which attenuates acute ischemic renal injury by modulating oxidative stress and cell death. NQDI-1 was used to study LPS-induced activation and role of ASK1 and p38 in anti-inflammatory cytokine production by macrophages Apoptosis signal-regulating kinase 1 (ASK1) is among the signaling events that lead to postischemic cell death. Inhibition of ASK1 pathway protected hearts from ischemic damage.
Hodoodo Cat#: H522544
Name: NQDI-1
CAS#: 175026-96-7
Chemical Formula: C19H13NO4
Exact Mass: 319.08
Molecular Weight: 319.316
Elemental Analysis: C, 71.47; H, 4.10; N, 4.39; O, 20.04
Synonym: NQDI1; NQDI-1; NQDI 1. CAS#175026-96-7
IUPAC/Chemical Name: ethyl 2,7-dioxo-2,7-dihydro-3H-naphtho[1,2,3-de]quinoline-1-carboxylate
InChi Key: UFJGFNHRMPMALC-UHFFFAOYSA-N
InChi Code: InChI=1S/C19H13NO4/c1-2-24-19(23)16-15-10-6-3-4-7-11(10)17(21)12-8-5-9-13(14(12)15)20-18(16)22/h3-9H,2H2,1H3,(H,20,22)
SMILES Code: O=C(C1=C2C3=C(NC1=O)C=CC=C3C(C4=C2C=CC=C4)=O)OCC
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 319.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Eaton GJ, Zhang QS, Diallo C, Matsuzawa A, Ichijo H, Steinbeck MJ, Freeman TA.
Inhibition of apoptosis signal-regulating kinase 1 enhances endochondral bone
formation by increasing chondrocyte survival. Cell Death Dis. 2014 Nov
13;5:e1522. doi: 10.1038/cddis.2014.480. PubMed PMID: 25393478; PubMed Central
PMCID: PMC4260738.
2: Yoshida T, Ozawa Y, Suzuki K, Yuki K, Ohyama M, Akamatsu W, Matsuzaki Y,
Shimmura S, Mitani K, Tsubota K, Okano H. The use of induced pluripotent stem
cells to reveal pathogenic gene mutations and explore treatments for retinitis
pigmentosa. Mol Brain. 2014 Jun 16;7:45. doi: 10.1186/1756-6606-7-45. PubMed
PMID: 24935155; PubMed Central PMCID: PMC4058693.
3: El Eter E. NQDI 1, an inhibitor of ASK1 attenuates acute ischemic renal injury
by modulating oxidative stress and cell death. Cardiovasc Hematol Agents Med
Chem. 2013 Sep;11(3):179-86. PubMed PMID: 23952292.
4: Nomura K, Lee M, Banks C, Lee G, Morris BJ. An ASK1-p38 signalling pathway
mediates hydrogen peroxide-induced toxicity in NG108-15 neuronal cells. Neurosci
Lett. 2013 Aug 9;549:163-7. doi: 10.1016/j.neulet.2013.05.045. Epub 2013 Jun 4.
PubMed PMID: 23742763.
5: Volynets GP, Chekanov MO, Synyugin AR, Golub AG, Kukharenko OP, Bdzhola VG,
Yarmoluk SM. Identification of 3H-naphtho[1,2,3-de]quinoline-2,7-diones as
inhibitors of apoptosis signal-regulating kinase 1 (ASK1). J Med Chem. 2011 Apr
28;54(8):2680-6. doi: 10.1021/jm200117h. Epub 2011 Mar 30. PubMed PMID: 21449566.
