RO5256390 HCl

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H522566

CAS#: 1043495-96-0 (free base)

Description: RO5256390 is a TAAR1 agonist. RO5256390 blocks psychostimulant-induced hyperactivity and produces a brain activation pattern reminiscent of the antipsychotic drug olanzapine, suggesting antipsychotic-like properties. TAAR1 activation promotes vigilance in rats and shows pro-cognitive and antidepressant-like properties in rodent and primate models. TAAR1 agonists may provide a novel and differentiated treatment of schizophrenia as compared with current medication standards: TAAR1 agonists may improve not only the positive symptoms but also the negative symptoms and cognitive deficits, without causing adverse effects such as motor impairments or weight gain.

Chemical Structure

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RO5256390 HCl
CAS# 1043495-96-0 (free base)
Instruction

Theoretical Analysis

Hodoodo Cat#: H522566
Name: RO5256390 HCl
CAS#: 1043495-96-0 (free base)
Chemical Formula: C13H20Cl2N2O
Exact Mass: 0.00
Molecular Weight: 291.216
Elemental Analysis: C, 53.62; H, 6.92; Cl, 24.35; N, 9.62; O, 5.49

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: RO5256390; RO-5256390; RO 5256390.

IUPAC/Chemical Name: (S)-4-((S)-2-phenylbutyl)-4,5-dihydrooxazol-2-amine dihydrochloride

InChi Key: NCOOUUDYVQYIDE-HFXMYSAISA-N

InChi Code: InChI=1S/C13H18N2O.2ClH/c1-2-10(11-6-4-3-5-7-11)8-12-9-16-13(14)15-12;;/h3-7,10,12H,2,8-9H2,1H3,(H2,14,15);2*1H/t10-,12-;;/m0../s1

SMILES Code: NC1=N[C@@H](C[C@@H](C2=CC=CC=C2)CC)CO1.[H]Cl.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info: Related CAS# 1043495-96-0 (RO5256390 free base) RO5256390 dihydrochloride CAS# is unknown.

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 291.22 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Pei Y, Mortas P, Hoener MC, Canales JJ. Selective activation of the trace
amine-associated receptor 1 decreases cocaine's reinforcing efficacy and prevents
cocaine-induced changes in brain reward thresholds. Prog Neuropsychopharmacol
Biol Psychiatry. 2015 Dec 3;63:70-5. doi: 10.1016/j.pnpbp.2015.05.014. Epub 2015
Jun 3. PubMed PMID: 26048337.


2: Pei Y, Lee J, Leo D, Gainetdinov RR, Hoener MC, Canales JJ. Activation of the
trace amine-associated receptor 1 prevents relapse to cocaine seeking.
Neuropsychopharmacology. 2014 Sep;39(10):2299-308. doi: 10.1038/npp.2014.88. Epub
2014 Apr 11. PubMed PMID: 24722355; PubMed Central PMCID: PMC4138750.


3: Revel FG, Moreau JL, Pouzet B, Mory R, Bradaia A, Buchy D, Metzler V, Chaboz
S, Groebke Zbinden K, Galley G, Norcross RD, Tuerck D, Bruns A, Morairty SR,
Kilduff TS, Wallace TL, Risterucci C, Wettstein JG, Hoener MC. A new perspective
for schizophrenia: TAAR1 agonists reveal antipsychotic- and antidepressant-like
activity, improve cognition and control body weight. Mol Psychiatry. 2013
May;18(5):543-56. doi: 10.1038/mp.2012.57. Epub 2012 May 29. PubMed PMID:
22641180.