WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H206548
CAS#: 57818-44-7 (free acid);
Description: ABTL0812 is an orally bioavailable, lipid analogue and inhibitor of raptor-mammalian target of rapamycin (mTOR) (mTOR complex 1; mTORC1), rictor-mTOR (mTOR complex 2; mTORC2) and dihydrofolate reductase (DHFR) with potential antineoplastic activity. Upon oral administration, mTORC1/mTORC2/DHFR inhibitor ABTL0812 binds to and inhibits both mTORC1 and mTORC2, which may result in apoptosis and a decrease in proliferation in mTORC1/2-expressing tumor cells.
Hodoodo Cat#: H206548
Name: ABTL0812 sodium
CAS#: 57818-44-7 (free acid);
Chemical Formula: C18H31NaO3
Exact Mass: 0.00
Molecular Weight: 318.433
Elemental Analysis: C, 67.89; H, 9.81; Na, 7.22; O, 15.07
This product is not in stock, which may be available by custom synthesis.
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Synonym: ABTL0812; ABTL-0812; ABTL 0812; sodium 2-hydroxylinoleate.
IUPAC/Chemical Name: sodium (9Z,12Z)-2-hydroxyoctadeca-9,12-dienoate
InChi Key: VFXKYDDSDQXKLC-NBTZWHCOSA-M
InChi Code: InChI=1S/C18H32O3.Na/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17(19)18(20)21;/h6-7,9-10,17,19H,2-5,8,11-16H2,1H3,(H,20,21);/q;+1/p-1/b7-6-,10-9-;
SMILES Code: CCCCC/C=C\C/C=C\CCCCCCC(O)C([O-])=O.[Na+]
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
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The following data is based on the product molecular weight 318.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |