WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H206549
CAS#: 1428774-45-1
Description: PF-06459988 is an orally available, small molecule, third-generation, irreversible inhibitor of epidermal growth factor receptor (EGFR) mutant (EGFRm) forms with potential antineoplastic activity. EGFR inhibitor PF-06459988 specifically binds to and inhibits mutant forms of EGFR, including the secondary acquired resistance mutation T790M, which prevents EGFR-mediated signaling and leads to cell death in EGFRm-expressing tumor cells. Compared to some other EGFR inhibitors, PF-06459988 may have therapeutic benefits in tumors with T790M-mediated drug resistance.
Hodoodo Cat#: H206549
Name: PF-06459988
CAS#: 1428774-45-1
Chemical Formula: C19H22ClN7O3
Exact Mass: 431.15
Molecular Weight: 431.881
Elemental Analysis: C, 52.84; H, 5.13; Cl, 8.21; N, 22.70; O, 11.11
Synonym: PF-06459988; PF06459988; PF 06459988; PF-6459988; PF 6459988; PF6459988.
IUPAC/Chemical Name: 1-((3R,4R)-3-(((5-chloro-2-((1-methyl-1H-pyrazol-4-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)methyl)-4-methoxypyrrolidin-1-yl)prop-2-en-1-one
InChi Key: ODMXWZROLKITMS-RISCZKNCSA-N
InChi Code: InChI=1S/C19H22ClN7O3/c1-4-15(28)27-7-11(14(9-27)29-3)10-30-18-16-13(20)6-21-17(16)24-19(25-18)23-12-5-22-26(2)8-12/h4-6,8,11,14H,1,7,9-10H2,2-3H3,(H2,21,23,24,25)/t11-,14+/m1/s1
SMILES Code: C=CC(N1C[C@H](COC2=C3C(NC=C3Cl)=NC(NC4=CN(C)N=C4)=N2)[C@@H](OC)C1)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 431.88 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Cheng H, Nair SK, Murray BW, Almaden C, Bailey S, Baxi S, Behenna DC,
Cho-Schultz S, Dalvie D, Dinh DM, Edwards MP, Feng JL, Ferre R, Gajiwala KS,
Hemkens MD, Jackson-Fisher A, Jalaie M, Johnson TO, Kania RS, Kephart S,
Lafontaine JA, Lunney E, Liu KK, Liu Z, Matthews J, Nagata A, Niessen S, Ornelas
MA, Orr ST, Pairish M, Planken S, Ren S, Richter DT, Ryan K, Sach NW, Shen H,
Smeal T, Solowiej J, Sutton SC, Tran K, Tseng E, Vernier WF, Walls M, Wang S,
Weinrich SL, Xin S, Xu H, Yin MJ, Zhou R, Zientek M, Kath J. Discovery of
1-{(3R,4R)-3-[5-Chloro-2-(1-methyl-1H-pyrazol-4-ylamino)-7H-pyrrolo[2,3-d]pyrimid
in-4-yloxymethyl]-4-methoxy-pyrrolidin-1-yl}propenone (PF-06459988), A Potent, WT
Sparing, Irreversible Inhibitor of T790M-Containing EGFR Mutants. J Med Chem.
2016 Jan 12. [Epub ahead of print] PubMed PMID: 26756222.
