WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H206572
CAS#: 1660110-65-5
Description: SC-III3 is a novel scopoletin derivative, induces autophagy of human hepatoma HepG2 cells through AMPK/mTOR signaling pathway by acting on mitochondria. SC-III3 reduces the viability of HepG2 cells and tumor growth of HepG2 xenograft mouse model. It induces the death of HepG2 cells by a way irrelevant to apoptosis and necrosis.
Hodoodo Cat#: H206572
Name: SC-III3
CAS#: 1660110-65-5
Chemical Formula: C19H14ClNO5
Exact Mass: 371.06
Molecular Weight: 371.773
Elemental Analysis: C, 61.38; H, 3.80; Cl, 9.54; N, 3.77; O, 21.52
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Synonym: SC-III3
IUPAC/Chemical Name: (E)-3-(4-chlorophenyl)-N-(7-hydroxy-6-methoxy-2-oxo-2H-chromen-3-yl) acrylamide
InChi Key:
InChi Code:
SMILES Code: O=C(NC(C1=O)=CC2=C(O1)C=C(O)C(OC)=C2)/C=C/C3=CC=C(Cl)C=C3
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 371.77 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Zhao P, Dou Y, Chen L, Li L, Wei Z, Yu J, Wu X, Dai Y, Xia Y. SC-III3, a novel
scopoletin derivative, induces autophagy of human hepatoma HepG2 cells through
AMPK/mTOR signaling pathway by acting on mitochondria. Fitoterapia. 2015
Jul;104:31-40. doi: 10.1016/j.fitote.2015.05.002. Epub 2015 May 8. PubMed PMID:
25964188.
2: Zhao P, Chen L, Li LH, Wei ZF, Tong B, Jia YG, Kong LY, Xia YF, Dai Y.
SC-III3, a novel scopoletin derivative, induces cytotoxicity in hepatocellular
cancer cells through oxidative DNA damage and ataxia telangiectasia-mutated
nuclear protein kinase activation. BMC Cancer. 2014 Dec 19;14:987. doi:
10.1186/1471-2407-14-987. PubMed PMID: 25527123; PubMed Central PMCID:
PMC4320555.