PF-04856264
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    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H522582

CAS#: 1235397-05-3

Description: PF-04856264 is a potent, selective inhibitor of the human Nav1.7 voltage gated sodium channel (IC50 = 28 nM). The voltage-gated sodium channel NaV1.7 is preferentially expressed in peripheral somatic and visceral sensory neurons, olfactory sensory neurons and sympathetic ganglion neurons. NaV1.7 is a major contributor to pain signalling in humans, and homology modelling based on crystal structures of ion channels suggests an atomic-level structural basis for the altered gating of mutant NaV1.7 that causes pain.

Chemical Structure

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PF-04856264
CAS# 1235397-05-3
Instruction

Theoretical Analysis

Hodoodo Cat#: H522582
Name: PF-04856264
CAS#: 1235397-05-3
Chemical Formula: C20H15N5O3S2
Exact Mass: 437.06
Molecular Weight: 437.492
Elemental Analysis: C, 54.91; H, 3.46; N, 16.01; O, 10.97; S, 14.66

Price and Availability

Size Price Availability Quantity
5mg USD 270 2 Weeks
25mg USD 720 2 Weeks
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Synonym: PF-04856264; PF04856264; PF 04856264; PF-4856264; PF4856264; PF 4856264.

IUPAC/Chemical Name: 3-cyano-4-(2-(1-methyl-1H-pyrazol-5-yl)phenoxy)-N-(thiazol-2-yl)benzenesulfonamide

InChi Key: MKSKJVIBSRUWSZ-UHFFFAOYSA-N

InChi Code: InChI=1S/C20H15N5O3S2/c1-25-17(8-9-23-25)16-4-2-3-5-19(16)28-18-7-6-15(12-14(18)13-21)30(26,27)24-20-22-10-11-29-20/h2-12H,1H3,(H,22,24)

SMILES Code: O=S(C1=CC=C(OC2=CC=CC=C2C3=CC=NN3C)C(C#N)=C1)(NC4=NC=CS4)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 437.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: McCormack K, Santos S, Chapman ML, Krafte DS, Marron BE, West CW, Krambis MJ,
Antonio BM, Zellmer SG, Printzenhoff D, Padilla KM, Lin Z, Wagoner PK, Swain NA,
Stupple PA, de Groot M, Butt RP, Castle NA. Voltage sensor interaction site for
selective small molecule inhibitors of voltage-gated sodium channels. Proc Natl
Acad Sci U S A. 2013 Jul 16;110(29):E2724-32. doi: 10.1073/pnas.1220844110. Epub
2013 Jul 1. PubMed PMID: 23818614; PubMed Central PMCID: PMC3718154.