WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H319788
CAS#: 347887-36-9
Description: Fedovapagon, also known as VA106483 and VT483, is a potent, nonpeptidic vasopressin V2 receptor agonist. Vasopressin (AVP) is a hormone that stimulates an increase in water permeability through activation of V2 receptors in the kidney.
Hodoodo Cat#: H319788
Name: Fedovapagon
CAS#: 347887-36-9
Chemical Formula: C27H34N4O3
Exact Mass: 462.26
Molecular Weight: 462.594
Elemental Analysis: C, 70.10; H, 7.41; N, 12.11; O, 10.38
Synonym: VA106483; VA-106483; VA 106483; VT483; VT-483; VT 483; Fedovapagon
IUPAC/Chemical Name: (S)-N2,N2-dimethyl-N1-(2-methyl-4-(2,3,4,5-tetrahydro-1H-benzo[b]azepine-1-carbonyl)benzyl)pyrrolidine-1,2-dicarboxamide
InChi Key: RUOLFWZIFNQQGH-DEOSSOPVSA-N
InChi Code: InChI=1S/C27H34N4O3/c1-19-17-21(25(32)30-15-7-6-10-20-9-4-5-11-23(20)30)13-14-22(19)18-28-27(34)31-16-8-12-24(31)26(33)29(2)3/h4-5,9,11,13-14,17,24H,6-8,10,12,15-16,18H2,1-3H3,(H,28,34)/t24-/m0/s1
SMILES Code: O=C(N1[C@H](C(N(C)C)=O)CCC1)NCC2=CC=C(C(N3CCCCC4=CC=CC=C43)=O)C=C2C
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 462.59 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Yea CM, Allan CE, Ashworth DM, Barnett J, Baxter AJ, Broadbridge JD, Franklin
RJ, Hampton SL, Hudson P, Horton JA, Jenkins PD, Penson AM, Pitt GR, Rivière P,
Robson PA, Rooker DP, Semple G, Sheppard A, Haigh RM, Roe MB. New benzylureas as
a novel series of potent, nonpeptidic vasopressin V2 receptor agonists. J Med
Chem. 2008 Dec 25;51(24):8124-34. doi: 10.1021/jm8008162. PubMed PMID: 19053774.