WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H319862
CAS#: 170381-16-5
Description: Zicronapine, also known as Lu 31-130, is an atypical antipsychotic medication. Zicronapine exhibits monoaminergic activity and has a multi-receptorial profile. In vitro and in vivo it has shown potent antagonistic effects at dopamine D1, D2 and serotonin 5HT2A receptors.
Hodoodo Cat#: H319862
Name: Zicronapine
CAS#: 170381-16-5
Chemical Formula: C22H27ClN2
Exact Mass: 354.19
Molecular Weight: 354.922
Elemental Analysis: C, 74.45; H, 7.67; Cl, 9.99; N, 7.89
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Synonym: Lu 31-130; Lu31-130; Lu-31-130; Lu 31130; Lu31130; Lu-31130; Zicronapine.
IUPAC/Chemical Name: 4-((1R,3S)-6-chloro-3-phenyl-2,3-dihydro-1H-inden-1-yl)-1,2,2-trimethylpiperazine
InChi Key: BYPMJBXPNZMNQD-PZJWPPBQSA-N
InChi Code: InChI=1S/C22H27ClN2/c1-22(2)15-25(12-11-24(22)3)21-14-19(16-7-5-4-6-8-16)18-10-9-17(23)13-20(18)21/h4-10,13,19,21H,11-12,14-15H2,1-3H3/t19-,21+/m0/s1
SMILES Code: CC1(C)N(C)CCN([C@@H]2C[C@@H](C3=CC=CC=C3)C4=C2C=C(Cl)C=C4)C1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info: In 2014 Lundbeck removed zicronapine from its development portfolio in favor of pursuing the more promising medicine Lu AF35700.
Biological target: | |
In vitro activity: | |
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The following data is based on the product molecular weight 354.92 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |