WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H319907
CAS#: 871576-03-3
Description: Flovagatran is a thrombin inhibitor.
Hodoodo Cat#: H319907
Name: Flovagatran
CAS#: 871576-03-3
Chemical Formula: C26H34BN3O6
Exact Mass: 495.25
Molecular Weight: 495.383
Elemental Analysis: C, 63.04; H, 6.92; B, 2.18; N, 8.48; O, 19.38
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Synonym: Flovagatran
IUPAC/Chemical Name: ((R)-1-((S)-N-(D-phenylalanyl)-1-((benzyloxy)carbonyl)pyrrolidine-2-carboxamido)butyl)boronic acid
InChi Key: OZTJDRUAULUCGY-VJBWXMMDSA-N
InChi Code: InChI=1S/C26H34BN3O6/c1-2-10-23(27(34)35)30(24(31)21(28)17-19-11-5-3-6-12-19)25(32)22-15-9-16-29(22)26(33)36-18-20-13-7-4-8-14-20/h3-8,11-14,21-23,34-35H,2,9-10,15-18,28H2,1H3/t21-,22+,23+/m1/s1
SMILES Code: CCC[C@H](N(C([C@@H](CC1=CC=CC=C1)N)=O)C([C@H]2N(C(OCC3=CC=CC=C3)=O)CCC2)=O)B(O)O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 495.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Gómez-Outes A, Suárez-Gea ML, Lecumberri R, Rocha E, Pozo-Hernández C,
Vargas-Castrillón E. New parenteral anticoagulants in development. Ther Adv
Cardiovasc Dis. 2011 Feb;5(1):33-59. doi: 10.1177/1753944710387808. Epub 2010 Nov
2. Review. PubMed PMID: 21045018.
2: Gómez-Outes A, Lecumberri R, Pozo C, Rocha E. New anticoagulants: focus on
venous thromboembolism. Curr Vasc Pharmacol. 2009 Jul;7(3):309-29. Review. PubMed
PMID: 19601856.