WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H522654
CAS#: 268545-87-5
Description: NBI-34041 is potent and high-affinity CRF1 receptor antagonist. NBI-34041 is safety and efficacy in attenuating elevated stress response. NBI-34041 is effective in reducing endocrine responses to pharmacological and behavioral challenge mediated by CRF(1) receptors. NBI-34041 is safe and does not impair basal regulation of the HPA system but improves resistance against psychosocial stress. NBI-34041 demonstrates that inhibition of the CRF system is a promising target for drug development against depression and anxiety disorders.
Hodoodo Cat#: H522654
Name: NBI-34041
CAS#: 268545-87-5
Chemical Formula: C22H26Cl2N4
Exact Mass: 416.15
Molecular Weight: 417.378
Elemental Analysis: C, 63.31; H, 6.28; Cl, 16.99; N, 13.42
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Synonym: NBI-34041; NBI 34041; NBI34041; SB-723620; SB723620; SB 723620
IUPAC/Chemical Name: 1-(2,4-dichlorophenyl)-5-(heptan-4-yl)-7-methyl-4,5-dihydro-3H-2,2a,5,8-tetraazaacenaphthylene
InChi Key: AKFWXFDMKRSYRD-UHFFFAOYSA-N
InChi Code: InChI=1S/C22H30N4O3/c1-7-10-25(11-12-27-4)20-13-15(2)23-22-21(16(3)24-26(20)22)18-9-8-17(28-5)14-19(18)29-6/h8-9,13-14H,7,10-12H2,1-6H3
SMILES Code: CCCC(N1C2=C3N(N=C(C4=CC=C(Cl)C=C4Cl)C3=NC(C)=C2)CC1)CCC
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 417.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Steckler T. Developing small molecule nonpeptidergic drugs for the treatment
of anxiety disorders: is the challenge still ahead? Curr Top Behav Neurosci.
2010;2:415-28. Review. PubMed PMID: 21309119.
2: Holsboer F, Ising M. Central CRH system in depression and anxiety--evidence
from clinical studies with CRH1 receptor antagonists. Eur J Pharmacol. 2008 Apr
7;583(2-3):350-7. doi: 10.1016/j.ejphar.2007.12.032. Epub 2008 Jan 24. Review.
PubMed PMID: 18272149.
3: Ising M, Holsboer F. CRH-sub-1 receptor antagonists for the treatment of
depression and anxiety. Exp Clin Psychopharmacol. 2007 Dec;15(6):519-28. doi:
10.1037/1064-1297.15.6.519. Review. PubMed PMID: 18179304.
4: Ising M, Zimmermann US, Künzel HE, Uhr M, Foster AC, Learned-Coughlin SM,
Holsboer F, Grigoriadis DE. High-affinity CRF1 receptor antagonist NBI-34041:
preclinical and clinical data suggest safety and efficacy in attenuating elevated
stress response. Neuropsychopharmacology. 2007 Sep;32(9):1941-9. Epub 2007 Feb 7.
PubMed PMID: 17287823.
